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Continuous theta burst stimulation provides neuroprotection by accelerating local cerebral blood flow and inhibiting inflammation in a mouse model of acute ischemic stroke.

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收录情况： ◇ SCIE

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机构： [a]Department of Rehabilitation Medicine, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China [b]Department of Rehabilitation Medicine, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, China [c]Guangdong Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China [d]Guangdong Provincial Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China [e]Department of Rehabilitation Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China [f]China National Clinical Research Center for Neurological Diseases, Beijing, China

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Acute ischemic stroke is a leading cause of disability with limited therapeutic options. Continuous theta burst stimulation (cTBS) has recently been shown to be a promising noninvasive therapeutic strategy for neuroprotection in ischemic stroke patients. Here, we investigated the protective effects of cTBS following acute infarction using a photothrombotic stroke (PTS) model in the right posterior parietal cortex (PPC) of C57BL/6 mice. Treatment with cTBS resulted in a reduction in the volume of the infarct region and significantly increased vascular diameter and blood flow velocity in peri-infarct region, as well as decreased the numbers of calcium binding adapter molecule 1 (Iba-1)-positive microglia and glial fibrillary acidic protein (GFAP)-positive astrocytes. Moreover, the number of CD16/32 positive microglia was decreased, whereas the number of CD206 positive microglia was increased. In addition, performance in a water maze task was significantly improved. These results indicated that cTBS protected against PPC infarct region, leading to an improvement in spatial cognitive function, possibly as a result of changes to cerebral microvascular function and inflammatory responses. Copyright © 2019 Elsevier B.V. All rights reserved.

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出版当年[2018]版：

大类 | 3 区医学

小类 | 3 区神经科学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区神经科学

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出版当年[2017]版：

Q2 NEUROSCIENCES

最新[2023]版：

Q3 NEUROSCIENCES

影响因子： 2.7 最新[2023版] 2.9 最新五年平均 3.125 出版当年[2017版] 2.929 出版当年五年平均 2.746 出版前一年[2016版] 2.929 出版后一年[2018版]

第一作者：

第一作者机构： [a]Department of Rehabilitation Medicine, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China

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通讯作者：

通讯机构： [a]Department of Rehabilitation Medicine, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China [b]Department of Rehabilitation Medicine, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, China [e]Department of Rehabilitation Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China [f]China National Clinical Research Center for Neurological Diseases, Beijing, China [*1]Department of Rehabilitation Medicine, Guangzhou First People’s Hospital, Guangzhou Medical University, The second Affiliated Hospital of South China University of Technology, 1 Panfu Road, Guangzhou 510180, China [*2]Department of Rehabilitation Medicine, Beijing Tiantan Hospital, Capital Medical University, No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070, China

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