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Risk factors of recurrent ischemic events after acute noncardiogenic ischemic stroke.

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收录情况： ◇ SCIE

作者：

机构： [1]Laboratory Diagnosis Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China [2]Beijing Engineering Research Center of Immunological Reagents Clinical Research, Beijing 100050, China [3]Department of Pharmacy, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China [4]Department of Radiology, Chinese PLA General Hospital, Beijing, 100853, China [5]Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Center of Stroke, Beijing Institute for Brain Disorders. Beijing, 100070, China

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摘要：

A considerable proportion of acute noncardiogenic ischemic stroke patients continue to experience recurrent ischemic events after standard therapy. We aimed to identify risk factors for recurrent ischemic event prediction at an early stage. 286 non-cardioembolic ischemic stroke patients with onset of symptoms less than three days were enrolled. Vascular risk factors, routine laboratory data on admission, thromboelastography test seven days after clopidogrel therapy and any recurrent events within one year were assessed. Recurrent ischemic events were observed in 43 patients. The risk of recurrent ischemic event was determined by receiver operating characteristic curve and multivariable logistic regression analysis. The mean levels of mean platelet volume (MPV), platelet/lymphocyte ratio (PLR), lymphocyte count (LY) and fibrinogen (Fib) on admission were significantly higher in the case group as compared to the control group (P<0.001). Seven days after clopidogrel therapy, the ADP-induced platelet aggregation ratio (ADP%) level was lower in case group, while the maximum amplitude (MA) level was higher in case group as compared to control group (P<0.01). The area under the curve of receiver operating characteristic curve of LY, PLR, , Fib, MA, ADP% and MPV were 0.602, 0.614, 0.629, 0.770, 0.800 and 0.808, respectively. The logistic regression analysis showed that MPV, ADP% and MA were indeed predictive factors. MPV, ADP% and MA were risk factors of recurrent ischemic events after acute noncardiogenic ischemic stroke. Urgent assessment and individual drug therapy should be offered to these patients as soon as possible. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

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中科院(CAS)分区：

出版当年[2018]版中科院分区表Review为是的期刊

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大类 | 3 区医学

小类 | 3 区药学

最新[2023]版

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大类 | 4 区医学

小类 | 4 区药学

JCR分区：

出版当年[2017]版：

Q2 PHARMACOLOGY & PHARMACY

最新[2023]版：

Q2 PHARMACOLOGY & PHARMACY

影响因子： 2.6 最新[2023版] 3 最新五年平均 2.757 出版当年[2017版] 2.962 出版当年五年平均 2.611 出版前一年[2016版] 2.412 出版后一年[2018版]

第一作者：

第一作者机构： [1]Laboratory Diagnosis Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China [2]Beijing Engineering Research Center of Immunological Reagents Clinical Research, Beijing 100050, China

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通讯作者：

通讯机构： [1]Laboratory Diagnosis Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China [2]Beijing Engineering Research Center of Immunological Reagents Clinical Research, Beijing 100050, China [4]Department of Radiology, Chinese PLA General Hospital, Beijing, 100853, China [5]Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Center of Stroke, Beijing Institute for Brain Disorders. Beijing, 100070, China [*1]Department of Radiology, Chinese PLA General Hospital, No. 28 Fuxing Rd, Beijing 100853, China [*2]Laboratory Diagnosis Center, Beijing Tiantan Hospital, Capital Medical University, No. 119, West Road of South Fourth Ring, Fengtai District, Beijing, 100070, China [*3]Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, No. 119, West Road of South Fourth Ring, Fengtai District, Beijing, 100070, China

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