个人科研网厅 | | 帮助
首都医科大学宣武医院知识库
高级检索
当前位置： 首页 > 详情页

Tau PET distributional pattern in AD patients with visuospatial dysfunction.

| 认领 | 导出 | |

文献详情

资源类型：

收录情况： ◇ SCIE

作者：
Sun Xi[1,2] * ; Nie Binbin[2,3,4] * ; Zhao Shujun[1] ; Chen Qian[8] ; Li Panlong[1,2] ; Zhang Tianhao[2,3] ; Pan Tingting[1,2] ; Feng Ting[1,2] ; Wang Luying[1,2] ; Yin Xiaolong[1,2] ; Zhang Wei[2,3] ; Zhao Shilun[2,3] ; Shan Baoci[2,3,4] ; Liu Hua[2,3,*1] ; Liang Shengxiang[5,6,*2] ; Ai Lin[8,*3] ; Wang Guihong[7,*4] ;
机构： [1]College of Physical Science and Technology, Zhengzhou University, Zhengzhou 450001, [2]Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China [3]School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing 100049, China [4]CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China [5]National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China [6]Traditional Chinese Medicine Rehabilitation Research Center of State Administration of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China [7]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100071, China [8]Department of Nuclear Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing 100071, China.
出处：
DOI： 10.2174/1567205016666191113152434
ISSN：

摘要：
Visuospatial dysfunction is one predominant symptom in many atypical Alzheimer's disease (AD) patients, however, until now its neural correlates still remain unclear. For the accumulation of intracellular hyperphosphorylated tau proteins is a major pathogenic factor in neurodegeneration of AD, the distributional pattern of tau could highlight the affected brain regions associated with specific cognitive deficits. We investigated the brain regions particularly affected by tau accumulation in patients with visuospatial dysfunction to explore its neural correlates. Using 18F-AV-1451 tau positron emission tomography (PET), voxel-wise two-sample t-tests were performed between AD patients with obvious visuospatial dysfunction (VS-AD) and cognitively normal subjects, AD patients with little-to-no visuospatial dysfunction (non VS-AD) and cognitively normal subjects, respectively. Results showed increased tau accumulations mainly located in occipitoparietal cortex, posterior cingulate cortex, precuneus, inferior and medial temporal cortex in VS-AD patients, while increased tau accumulations mainly occurred in the inferior and medial temporal cortex in non VS-AD patients. These findings suggested that occipitoparietal cortex, posterior cingulate cortex and precuneus, which were particularly affected by increased tau accumulation in VS-AD patients, may associate with visuospatial dysfunction of AD. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类 | 3 区 医学
小类 | 3 区 临床神经病学 3 区 神经科学
最新[2023]版：
大类 | 4 区 医学
小类 | 4 区 临床神经病学 4 区 神经科学
JCR分区：
出版当年[2017]版：
Q2 CLINICAL NEUROLOGY Q2 NEUROSCIENCES
最新[2023]版：
Q3 CLINICAL NEUROLOGY Q4 NEUROSCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2017版] 出版当年五年平均 出版前一年[2016版] 出版后一年[2018版]

第一作者：
第一作者机构： [1]College of Physical Science and Technology, Zhengzhou University, Zhengzhou 450001, [2]Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
共同第一作者：
通讯作者：
通讯机构： [2]Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China [3]School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing 100049, China [5]National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China [6]Traditional Chinese Medicine Rehabilitation Research Center of State Administration of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China [7]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100071, China [8]Department of Nuclear Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing 100071, China. [*1]Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China [*2]National- Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fuzhou, China [*3]Department of Nuclear Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing 100071, China [*4]Department of Neurology, Tiantan Hospital, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Sun Xi,Nie Binbin,Zhao Shujun,et al.Tau PET distributional pattern in AD patients with visuospatial dysfunction.[J].Current Alzheimer research.2019,doi:10.2174/1567205016666191113152434.
APA：
Sun Xi,Nie Binbin,Zhao Shujun,Chen Qian,Li Panlong...&Wang Guihong.(2019).Tau PET distributional pattern in AD patients with visuospatial dysfunction..Current Alzheimer research,,
MLA：
Sun Xi,et al."Tau PET distributional pattern in AD patients with visuospatial dysfunction.".Current Alzheimer research .(2019)

资源点击量：16461 今日访问量：0 总访问量：871 更新日期：2025-01-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 首都医科大学宣武医院 技术支持：重庆聚合科技有限公司 地址：北京市西城区长椿街45号宣武医院