机构：[1]Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Virology Laboratory, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.医技科室科研平台职能科室感染科呼吸疾病研究室临床流行病与循证医学中心临床研究中心儿科研究所首都医科大学附属北京儿童医院[2]Department of Microbiology, School of Basic Medical Sciences, Chinese Capital Medical University, Beijing 100069, China.[3]Beijing Tropical Medicine Research Institute, Beijing Friendship Hospital, Second Clinical Medical College of Capital Medical University, Beijing 100050, China.[4]Center of Epilepsy, Beijing Institute for Brain Disorders, Beijing 100069, China.
The development of an effective tetravalent vaccine against dengue viruses (DENVs) has become a world priority. We previously showed that four monovalent dengue DNA vaccines expressing premembrane (prM) and envelope (E) proteins displayed effective protection against corresponding challenges in mice. Thus, to elucidate the overall immunity and persistence of the tetravalent formulation (TetraME), we evaluated the humoral and cellular immune responses as well as the long-term protection in the current study. TetraME-immunized mice displayed increased production of Th1/Th2-typed cytokines upon stimulation with heterologous DENV antigens. Moreover, high levels of tetravalent DENV antibodies and sterilized immunity were detected long-term (30 weeks after immunization). These findings provide feasible validation for the potential utility of this vaccine formulation.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
无
最新[2023]版：
大类|1 区生物学
小类|1 区动物学
第一作者：
第一作者机构：[1]Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Virology Laboratory, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.[2]Department of Microbiology, School of Basic Medical Sciences, Chinese Capital Medical University, Beijing 100069, China.
共同第一作者：
通讯作者：
通讯机构：[2]Department of Microbiology, School of Basic Medical Sciences, Chinese Capital Medical University, Beijing 100069, China.
推荐引用方式(GB/T 7714)：
Wang Ran,Yang Fu-Jia,Zheng Xiao-Yan,et al.Long-term protection against dengue viruses in mice conferred by a tetravalent DNA vaccine candidate.[J].Zoological research.2019,1-4.doi:10.24272/j.issn.2095-8137.2020.016.
APA：
Wang Ran,Yang Fu-Jia,Zheng Xiao-Yan,Liao Xian-Zheng,Fan Dong-Ying...&An Jing.(2019).Long-term protection against dengue viruses in mice conferred by a tetravalent DNA vaccine candidate..Zoological research,,
MLA：
Wang Ran,et al."Long-term protection against dengue viruses in mice conferred by a tetravalent DNA vaccine candidate.".Zoological research .(2019):1-4
