Purpose: To evaluate surgical outcomes and cognitive improvements after posterior quadrantic disconnection (PQD) in children who had medically intractable epilepsy and to compare the various characteristics between the acquired group and the developmental group.Method: Between 2015 and 2017, we retrospectively enrolled all pediatric patients who underwent PQD. We used image post-processing techniques for preoperative evaluation. Seizure outcomes and postoperative cognitive improvements were analysed. The patients were divided into the acquired group and the developmental group depending on the pathology; we then compared groups regarding age at onset, surgery, history, and seizure and cognitive outcomes.Results: A total of 12 pediatric patients were enrolled, including 7 acquired patients and 5 developmental patients. After a median 28.9-month follow-up, 11 (91.7%) of 12 patients were seizure free. The image post-processing facilitated a better visualization on preoperative evaluation and helped with detection of the epileptogenic zone. There were significant linear relationships between improvements in IQ and operative age (R2=0.527, p = 0.007) and IQ and epileptic history (R2=0.696, p = 0.001). The median age at seizure onset was 4.86 ± 2.12 years in the acquired group and 2.40 ± 1.14 years in the developmental group (t = 2.344, p = 0.028). Epileptic histories, seizure outcomes and cognitive outcomes were not significantly different between groups.Conclusion: Posterior quadrantic disconnection is an effective epilepsy surgery in selected patients. The use of image post-processing is important for preoperative evaluation. The age at seizure onset and surgery in malformation of cortical development (MCD) patients was earlier; however, the seizure outcome was no better than in acquired pathology patients. Early surgery did not change seizure outcomes but improved cognition.