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Microstructure and functional connectivity-based evidence for memory-related regional impairments in the brains of pilocarpine-treated rats.

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收录情况： ◇ SCIE

作者：

机构： [a]Department of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China [b]Beijing Key Laboratory of Neurostimulation, Beijing, China [c]Department of Functional Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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摘要：

Patients with temporal lobe epilepsy (TLE) frequently suffer from memory disorders, and the pathological changes show widespread regional impairments in the brain. In lithium-pilocarpine (LIP)-treated rats with TLE, an abnormal hippocampal microstructure and functional connectivity have been observed. However, changes in other brain regions are still unclear. In the present study, diffusion tensor imaging and functional magnetic resonance imaging (MRI) signals were collected in LIP-TLE rats and controls using a 7.0 T MRI. Microstructural parameters and functional connectivity were calculated among regions of interest (ROIs), including the bilateral prefrontal cortex, amygdala, hippocampus and entorhinal cortex. A correlation analysis was further performed between the neuroimaging results and the behavioral performance in the novel object and novel location memory tests. In our results, TLE rats showed increased fractional anisotropy (FA) values in the hippocampus and decreased FA values in the amygdala and entorhinal cortex. In addition, decreased functional connectivity between the amygdala and the CA3, and increased connectivity between the prefrontal cortex and the CA1 were observed in the TLE rats compared to control rats. Moreover, FA values in the amygdala, the hippocampus and the entorhinal cortex, as well as the amygdala-CA3 and the prefrontal-CA1 connectivity correlated with the memory performance. Based on our results, both the microstructure and functional connections were impaired in memory-related brain regions of LIP-TLE rats. Furthermore, the abnormal changes in the microstructure and functional connectivity were related to behavioral deficits in object and location memory. Copyright © 2019 Elsevier Inc. All rights reserved.

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中科院(CAS)分区：

出版当年[2018]版：

大类 | 3 区医学

小类 | 3 区神经科学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区神经科学

JCR分区：

出版当年[2017]版：

Q2 NEUROSCIENCES

最新[2023]版：

Q2 NEUROSCIENCES

影响因子： 3.5 最新[2023版] 3.6 最新五年平均 3.44 出版当年[2017版] 3.074 出版当年五年平均 3.033 出版前一年[2016版] 3.103 出版后一年[2018版]

第一作者：

第一作者机构： [a]Department of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China [b]Beijing Key Laboratory of Neurostimulation, Beijing, China [*1]Beijing Neurosurgical Institute, 119 South 4th Ring West Rd, Fengtai District, Beijing, China.

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通讯作者：

通讯机构： [a]Department of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China [b]Beijing Key Laboratory of Neurostimulation, Beijing, China [c]Department of Functional Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China [*1]Beijing Neurosurgical Institute, 119 South 4th Ring West Rd, Fengtai District, Beijing, China.

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