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Robust and stable small-world topology of brain intrinsic organization during pre- and post-task resting states

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机构: [a]International WIC Institute, Beijing University of Technology, China [b]Beijing Municipal Lab. of Brain Informatics, China [c]Dept. of Computer Science, Hong Kong Baptist University, Hong Kong [d]Dept. of Life Science and Informatics, Maebashi Institute of Technology, Japan [e]Dept. of Psychology, Carnegie Mellon University, United States [f]Dept. of Radiology, Xuanwu Hospital, Capital Medical University, China
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Brain functional network studies have demonstrated the small-world topology as the nature of large-scale spontaneous brain activity. Studies have also revealed that the temporal coherence of spontaneous activity could be reshaped during task-dependent (or post-task) resting states within local spatial patterns such as task-related and the default-mode networks. However, to our best knowledge, it is still a lack of rigorous investigations that whether the small-world topology of spontaneous intrinsic organization remains robust and stable during different resting states. To address the problem, we recorded blood oxygen level-dependent (BOLD) signals from two rests (namely, pre- and post-task resting states) before and after a simple semantic-matching task, and investigated the preceding task influences on the topology of the large-scale spontaneous intrinsic organization during the post-task resting state. The major findings are that the small-world configuration of spontaneous intrinsic organization remains robust and stable during resting states regardless of preceding task influences. © 2011 Springer-Verlag.

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