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Association of toll-like receptor 10 polymorphisms with pediatric pneumococcal meningitis.

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收录情况： ◇ SCIE

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机构： [a]Department of Medical Microbiology, Capital Medical University, Beijing, China [b]Department of Infectious Diseases, Beijing Children’s Hospital, Capital Medical University,Beijing, China [c]Department of Laboratory Medicine, the Sixth Medical Center, Chinese PLA General Hospital,Beijing, China [d]Department of Medical Microbiology and Immunology, University of Turku, Turku, Finland

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关键词： Bacteriology children clinical microbiology cytokines gene polymorphisms immunology interleukins pneumococcal meningitis prognostic markers TLR10

摘要：

We aimed to investigate whether the gene polymorphisms of TLR10 was associated with risk and severity of pneumococcal meningitis (PM) and serum cytokine levels in children. Three single nucleotide polymorphisms (SNPs) of TLR10 rs4129009 (2676A>G), rs10004195 (1018T>A) and rs11466617 (40735A>G) were studied in 95 laboratory-confirmed PM pediatric patients and 330 healthy controls by PCR-based sequencing. Ten serum cytokines were determined by multiplex immunoassay. The frequency of variant haplotype GAG of TLR10 was significantly lower in patients than controls (11.3% vs. 33.3%, p <0.001), although frequencies of the genotypes and alleles of the three SNPs did not differ between patients and controls. Frequency of variant haplotype GAG was significantly lower in patients who had CSF protein > 1000 mg/L than those who had CSF protein ≤1000 mg/L (3.50% vs. 32.4%, p <0.001). Moreover, higher frequency of the haplotype GAG was found in patients who had higher levels of inflammatory cytokines such as IFN-γ, TNF-α and IL-1β. Our finding suggested that the variant haplotype GAG in TLR10 is associated with decreased risk of PM in Chinese children. © 2020 APMIS. Published by John Wiley & Sons Ltd.

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出版当年[2019]版：

大类 | 4 区医学

小类 | 3 区病理学 4 区免疫学 4 区微生物学

最新[2023]版：

大类 | 4 区医学

小类 | 3 区病理学 4 区免疫学 4 区微生物学

JCR分区：

出版当年[2018]版：

Q2 PATHOLOGY Q3 MICROBIOLOGY Q4 IMMUNOLOGY

最新[2023]版：

Q3 MICROBIOLOGY Q3 PATHOLOGY Q4 IMMUNOLOGY

影响因子： 2.2 最新[2023版] 2.6 最新五年平均 2.225 出版当年[2018版] 2.009 出版当年五年平均 2.026 出版前一年[2017版] 2.406 出版后一年[2019版]

第一作者：

第一作者机构： [a]Department of Medical Microbiology, Capital Medical University, Beijing, China

通讯作者：

通讯机构： [a]Department of Medical Microbiology, Capital Medical University, Beijing, China [d]Department of Medical Microbiology and Immunology, University of Turku, Turku, Finland [*1]Department of Medical Microbiology, Capital Medical University, 100069, Beijing, China

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