个人科研网厅 | | 帮助
首都医科大学宣武医院知识库
高级检索
当前位置： 首页 > 详情页

Single-Cell Transcriptomic Atlas of Primate Ovarian Aging.

| 导出 | |

文献详情

资源类型：
WOS体系：

收录情况： ◇ SCIE ◇ 自然指数

作者：
Si Wang[1,3,4,5,7] * ; Yuxuan Zheng[2,9,10] * ; Jingyi Li[1,4,5,7] * ; Yang Yu[6,12] * ; Weiqi Zhang[4,5,7,8,13] * ; Moshi Song[1,7,8] ; Zunpeng Liu[3,7] ; Zheying Min[6] ; Huifang Hu[3,7] ; Ying Jing[3,7] ; Xiaojuan He[5] ; Liang Sun[14] ; Lifang Ma[6] ; Concepcion Rodriguez Esteban[11] ; Piu Chan[5] ; Jie Qiao[6] ; Qi Zhou[3,7,8] ; Juan Carlos Izpisua Belmonte[11] ; Jing Qu[3,7,8] ; Fuchou Tang[2,9,10] ; Guang-Hui Liu[1,4,5,7,8] ;
机构： [1]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2]Beijing Advanced Innovation Center for Genomics, College of Life Sciences, Peking University, Beijing 100871, China [3]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [4]National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China [5]Beijing Institute for Brain Disorders, Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China [6]Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Peking University Third Hospital, Beijing 100191, China [7]University of Chinese Academy of Sciences, Beijing 100049, China [8]Institute for Stem cell and Regeneration, CAS, Beijing 100101, China [9]Biomedical Institute for Pioneering Investigation via Convergence, Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Beijing 100871, China [10]Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China [11]Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California, United States of America [12]Stem Cell Research Center, Peking University Third Hospital, Beijing 100191, China [13]Disease Genomics and Individualized Medicine Laboratory, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China [14]The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing 100730, China
出处：
DOI： 10.1016/j.cell.2020.01.009
ISSN：

摘要：
Molecular mechanisms of ovarian aging and female age-related fertility decline remain unclear. We surveyed the single-cell transcriptomic landscape of ovaries from young and aged non-human primates (NHPs) and identified seven ovarian cell types with distinct gene-expression signatures, including oocyte and six types of ovarian somatic cells. In-depth dissection of gene-expression dynamics of oocytes revealed four subtypes at sequential and stepwise developmental stages. Further analysis of cell-type-specific aging-associated transcriptional changes uncovered the disturbance of antioxidant signaling specific to early-stage oocytes and granulosa cells, indicative of oxidative damage as a crucial factor in ovarian functional decline with age. Additionally, inactivated antioxidative pathways, increased reactive oxygen species, and apoptosis were observed in granulosa cells from aged women. This study provides a comprehensive understanding of the cell-type-specific mechanisms underlying primate ovarian aging at single-cell resolution, revealing new diagnostic biomarkers and potential therapeutic targets for age-related human ovarian disorders. Copyright © 2020 Elsevier Inc. All rights reserved.

基金：
This work was supported by the National Key Research and Development Program of China (2018YFC2000100), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA16010100), the National Key Research and Development Program of China (2017YFA0102802, 2017YFA0103304, 2018YFC1003101, 2015CB964800, 2016YFC1000601, 2018YFA0107203, 2018YFC2000400), the National Natural Science Foundation of China (81921006, 81625009, 91749202, 91749123, 31671429, 81671377, 81771515, 31601158, 81701388, 81601233, 31601109, 81822018, 81870228, 81801399, 31801010, 81801370, 81861168034, 31900523, 81901432, 81901433, 31900524, 81922027, 81571400, 81771580, 81971381, 81730038, 81571385, 91849132, 91949209), Beijing Natural Science Foundation (Z190019), Program of Beijing Municipal Science and Technology Commission (Z191100001519005), Beijing Municipal Commission of Health and Family Planning (PXM2018_026283_000002), the Key Research Program of the Chinese Academy of Sciences (KFZD-SW-221), Advanced Innovation Center for Human Brain Protection (3500-1192012), Young Elite Scientists Sponsorship Program by CAST (2017QNRC001), the State Key Laboratory of Membrane Biology, and the Strategic Collaborative Research Program of the Ferring Institute of Reproductive Medicine, Ferring Pharmaceuticals and the Chinese Academy of Sciences (FIRMC180305). J.C.I.B. was supported by UCAM, the Moxie Foundation, and the Glenn Foundation.
语种：
外文
高被引：
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类 | 1 区 生物
小类 | 1 区 生化与分子生物学 1 区 细胞生物学
最新[2023]版：
大类 | 1 区 生物学
小类 | 1 区 生化与分子生物学 1 区 细胞生物学
JCR分区：
出版当年[2018]版：
Q1 CELL BIOLOGY Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
最新[2023]版：
Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 CELL BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

第一作者：
第一作者机构： [1]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [3]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [4]National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China [5]Beijing Institute for Brain Disorders, Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China [7]University of Chinese Academy of Sciences, Beijing 100049, China
共同第一作者：
通讯作者：
通讯机构： [1]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2]Beijing Advanced Innovation Center for Genomics, College of Life Sciences, Peking University, Beijing 100871, China [3]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [4]National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China [5]Beijing Institute for Brain Disorders, Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China [7]University of Chinese Academy of Sciences, Beijing 100049, China [8]Institute for Stem cell and Regeneration, CAS, Beijing 100101, China [9]Biomedical Institute for Pioneering Investigation via Convergence, Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Beijing 100871, China [10]Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China [11]Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California, United States of America
推荐引用方式(GB/T 7714)：
Si Wang,Yuxuan Zheng,Jingyi Li,et al.Single-Cell Transcriptomic Atlas of Primate Ovarian Aging.[J].CELL.2020,180(3):585-600.e19.doi:10.1016/j.cell.2020.01.009.
APA：
Si Wang,Yuxuan Zheng,Jingyi Li,Yang Yu,Weiqi Zhang...&Guang-Hui Liu.(2020).Single-Cell Transcriptomic Atlas of Primate Ovarian Aging..CELL,180,(3)
MLA：
Si Wang,et al."Single-Cell Transcriptomic Atlas of Primate Ovarian Aging.".CELL 180..3(2020):585-600.e19

资源点击量：16409 今日访问量：0 总访问量：869 更新日期：2025-01-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 首都医科大学宣武医院 技术支持：重庆聚合科技有限公司 地址：北京市西城区长椿街45号宣武医院