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Elevation of stromal cell-derived factor 1 and C-X-C chemokine receptor type 4 in white matter damage treatment with recombinant human erythropoietin and human umbilical cord mesenchymal stem cells in a rat model of preterm birth.

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机构： [1]Department of Pediatrics, Zhongda Hospital, Southeast University, Nanjing, China. [2]Teaching and Research Section of Pediatrics, Medical College, Southeast University, Nanjing, China. [3]Department of Pediatrics, Xuanwu Hospital Medical University, Beijing, China. [4]Neonatal Intensive Care Unit, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, China.

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关键词： CXC family chemokine 4 human umbilical cord mesenchymal stem cells hypoxia-ischemia premature rats recombinant human erythropoietin stromal cell-derived factor 1 white matter damage

摘要：

To investigate the role of stromal cell-derived factor 1 (SDF-1) and C-X-C chemokine receptor type 4 (CXCR-4) in the premature brain with white matter damage (WMD) undergoing treatment with human umbilical cord mesenchymal stem cells (hUC-MSCs) and recombinant human erythropoietin (rhEPO). Three-day-old Sprague-Dawley (SD) rats were randomly divided into sham operation group, hypoxia-ischemia (HI) group, rhEPO treated HI group, hUC-MSCs treated HI group, and rhEPO + hUC-MSCs treated HI group. WMD was established in all groups except the Sham group. SDF-1 and CXCR-4 levels in each group were detected at postnatal day (P) 5, P7, and P14. Pathological changes were assessed via HE staining at P14 and neuroethological tests were performed at P28. The rhEPO and hUC-MSCs intervention reduced injury area, increased body weight at P7, and improved neurobehavioral scores at P28. Furthermore, their combined use proved even more beneficial. SDF-1 levels in the rhEPO group were higher than those in the other groups and highest in the hUC-MSCs + rhEPO group (all p < .01). SDF-1 levels in the hUC-MSCs + rhEPO and rhEPO groups were increased at P5 and reached a peak at P7. CXCR-4 levels in the hUC-MSCs group were higher than those in the other groups and highest in the hUC-MSCs + rhEPO group (all p < .01). CXCR-4 levels were also increased at P5 and highest at P14. hUC-MSCs + rhEPO might reduce nerve cell damage and improve neurobehavioral development, in connection with increased SDF-1 and CXCR-4 expression, in premature rats with WMD due to hypoxic-ischemic injury. © 2020 International Society for Developmental Neuroscience.

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出版当年[2019]版：

大类 | 3 区医学

小类 | 3 区发育生物学 4 区神经科学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区发育生物学 4 区神经科学

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出版当年[2018]版：

Q2 DEVELOPMENTAL BIOLOGY Q3 NEUROSCIENCES

最新[2023]版：

Q3 DEVELOPMENTAL BIOLOGY Q4 NEUROSCIENCES

影响因子： 1.7 最新[2023版] 2 最新五年平均 2.367 出版当年[2018版] 2.398 出版当年五年平均 2.495 出版前一年[2017版] 1.911 出版后一年[2019版]

第一作者：

第一作者机构： [1]Department of Pediatrics, Zhongda Hospital, Southeast University, Nanjing, China. [2]Teaching and Research Section of Pediatrics, Medical College, Southeast University, Nanjing, China.

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Elevation of stromal cell-derived factor 1 and C-X-C chemokine receptor type 4 in white matter damage treatment with recombinant human erythropoietin and human umbilical cord mesenchymal stem cells in a rat model of preterm birth.

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