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Multiparametric imaging hippocampal neurodegeneration and functional connectivity with simultaneous PET/MRI in Alzheimer’s disease

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收录情况： ◇ SCIE

作者：
Shaozhen Yan[1,2,3] * ; Chaojie Zheng[2] ; Bixiao Cui[4] ; Zhigang Qi[1,3] ; Zhilian Zhao[1,3] ; Yanhong An[1,3] ; Liyan Qiao[5] ; Ying Han[6] ; Yun Zhou[2] ; Jie Lu[1,3,4] ;
机构： [1]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China [2]Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 Kingshighway Blvd., St. Louis, MO, USA [3]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China [4]Department of Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China [5]Department of Neurology, Yuquan Hospital, Clinical Neuroscience Institute, Medical Center, Tsinghua University, Beijing, China [6]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China
出处：
DOI： 10.1007/s00259-020-04752-8
ISSN：

关键词： Alzheimer’s disease Hippocampal subregions Hybrid PET/MRI Neurodegeneration Voxel-based morphometric analysis

摘要：
Purpose: The objective of this study is to investigate the hippocampal neurodegeneration and its associated aberrant functions in mild cognitive impairment (MCI) and Alzheimer’s disease (AD) patients using simultaneous PET/MRI. Methods: Forty-two cognitively normal controls (NC), 38 MCI, and 22 AD patients were enrolled in this study. All subjects underwent 18F-FDG PET/functional MRI (fMRI) and high-resolution T1-weighted MRI scans on a hybrid GE Signa PET/MRI scanner. Neurodegeneration in hippocampus and its subregions was quantified by regional gray matter volume and 18F-FDG standardized uptake value ratio (SUVR) relative to cerebellum. An iterative reblurred Van Cittert iteration method was used for voxelwise partial volume correction on 18F-FDG PET images. Regional gray matter volume was estimated from voxel-based morphometric analysis with MRI. fMRI data were analyzed after slice time correction and head motion correction using statistical parametric mapping (SPM12) with DPARSF toolbox. The regions of interest including hippocampus, cornu ammonis (CA1), CA2/3/dentate gyrus (DG), and subiculum were defined in the standard MNI space. Results: Patient groups had reduced SUVR, gray matter volume, and functional connectivity compared to NC in CA1, CA2/3/DG, and subiculum (AD < MCI < NC). There was a linear correlation between the left CA2/3DG gray matter volume and 18F-FDG SUVR in AD patients (P < 0.001, r = 0.737). Significant correlation was also found between left CA2/3/DG-superior medial frontal gyrus functional connectivity and left CA2/3/DG hypometabolism in patients with AD. The functional connectivity of right CA1-precuneus in patients with MCI and right subiculum-superior frontal gyrus in patients with AD was positively correlated with mini mental status examination scores (P < 0.05). Conclusion: Our findings demonstrate that the associations existed at subregional hippocampal level between the functional connectivity measured by fMRI and neurodegeneration measured by structural MRI and 18F-FDG PET. Our results may provide a basis for precision neuroimaging of hippocampus in AD. © 2020, The Author(s).

基金：
国家自然科学基金
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类 | 1 区 医学
小类 | 1 区 核医学
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 核医学
JCR分区：
出版当年[2018]版：
Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版：
Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

影响因子： 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

第一作者：
第一作者机构： [1]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China [2]Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 Kingshighway Blvd., St. Louis, MO, USA [3]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China
通讯作者：
通讯机构： [1]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China [2]Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 Kingshighway Blvd., St. Louis, MO, USA [3]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China [4]Department of Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Shaozhen Yan,Chaojie Zheng,Bixiao Cui,et al.Multiparametric imaging hippocampal neurodegeneration and functional connectivity with simultaneous PET/MRI in Alzheimer’s disease[J].European journal of nuclear medicine and molecular imaging.2020,47(10):2440-2452.doi:10.1007/s00259-020-04752-8.
APA：
Shaozhen Yan,Chaojie Zheng,Bixiao Cui,Zhigang Qi,Zhilian Zhao...&Jie Lu.(2020).Multiparametric imaging hippocampal neurodegeneration and functional connectivity with simultaneous PET/MRI in Alzheimer’s disease.European journal of nuclear medicine and molecular imaging,47,(10)
MLA：
Shaozhen Yan,et al."Multiparametric imaging hippocampal neurodegeneration and functional connectivity with simultaneous PET/MRI in Alzheimer’s disease".European journal of nuclear medicine and molecular imaging 47..10(2020):2440-2452

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