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Low expression of FOSL1 is associated with favorable prognosis and sensitivity to radiation/pharmaceutical therapy in lower grade glioma.

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机构： [1]Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China. [2]Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. [3]Department of Neurosurgery, Yuquan Hospital, Tsinghua University, Beijing, China.

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Objectives: FOSL1 is overexpressed in multiple cancers including malignant glioma and contributes to different cellular processes. However, little attention has been paid to the lower grade glioma (LGG).Methods: Cox coefficients were examined to compare FOSL1 expression among different tumors types using OncoLnc. The UCSC Xena browser was used to generate Kaplan-Meier survival curves and explore the association between FOSL1 expression and overall survival (OS) in TCGA-LGG and subgroups.Results: FOSL1 expression in LGG was ranked first among 21 different cancers. LGG with lower FOSL1 expression had longer OS (P < 0.001). The astrocytoma group had the highest FOSL1 expression and shortest OS, followed by oligoastrocytoma and oligodendroglioma (P < 0.05). The 1p19q co-deletion or IDH mutation subgroups had lower FOSL1 expression and longer OS (P < 0.001). Compared with the corresponding groups, LGG with lower FOSL1 expression had longer OS than the following groups: astrocytoma, oligodendroglioma, with/without 1p19q co-deletion, with IDH mutation, with radiation, and with pharmaceutical therapy (P < 0.05).Discussion: FOSL1 is a prognostic marker in LGG and subgroups.

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出版当年[2019]版：

大类 | 4 区医学

小类 | 4 区临床神经病学 4 区神经科学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区临床神经病学 4 区神经科学

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出版当年[2018]版：

Q3 CLINICAL NEUROLOGY Q4 NEUROSCIENCES

最新[2023]版：

Q3 CLINICAL NEUROLOGY Q4 NEUROSCIENCES

影响因子： 1.7 最新[2023版] 2.2 最新五年平均 1.983 出版当年[2018版] 1.773 出版当年五年平均 1.449 出版前一年[2017版] 2.401 出版后一年[2019版]

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第一作者机构： [1]Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.

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