机构：[1]School of Life Science, Beijing Institute of Technology, Beijing, China[2]College of Information and Computer, Taiyuan University of Technology, Taiyuan, Shanxi, China[3]Translational Medicine Research Center, Shanxi Medical University, Taiyuan, Shanxi, China[4]Department of Neurology, Beijing Rehabilitation Hospital, Capital Medical University, Beijing, China[5]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China神经科系统神经内科首都医科大学宣武医院[6]Advanced research institute of multidisciplinary science, Beijing Institute of Technology, Beijing, China[7]Key Laboratory of Biomimetic Robots and Systems, Ministry of Education, Beijing Institute of Technology, Beijing, China
The apolipoprotein E (APOE) ε4 allele is a genetic risk factor for Alzheimer's disease, whereas educational attainments have protective effects against cognitive decline in aging and patients with Alzheimer's disease. We examined the possible effects of years of education and APOE genotype on the topological properties of the functional network in normal aging, mild cognitive impairment and Alzheimer's disease. The years of education showed a significant, negative association with the local efficiency, clustering coefficient and small-worldness of functional networks in APOE ε4 noncarriers but not in ε4 carriers. These associations were mainly observed in normal aging and were reduced in mild cognitive impairment and Alzheimer's disease. Moreover, regions of the inferior frontal gyrus, temporal pole, and cuneus also showed correlations between education and nodal degree. Our findings demonstrated that the protective effects of education persist in APOE ε4 noncarriers but diminish in ε4 carriers. In addition, the protective effects of education were attenuated or reduced in the progression of Alzheimer's disease.
第一作者机构：[1]School of Life Science, Beijing Institute of Technology, Beijing, China
推荐引用方式(GB/T 7714)：
Li Ting,Wang Bin,Gao Yuan,et al.APOE ε4 and cognitive reserve effects on the functional network in the Alzheimer's disease spectrum.[J].Brain imaging and behavior.2021,15(2):doi:10.1007/s11682-020-00283-w.
APA：
Li Ting,Wang Bin,Gao Yuan,Wang Xin,Yan Ting...&the Alzheimer’s Disease Neuroimaging Initiative.(2021).APOE ε4 and cognitive reserve effects on the functional network in the Alzheimer's disease spectrum..Brain imaging and behavior,15,(2)
MLA：
Li Ting,et al."APOE ε4 and cognitive reserve effects on the functional network in the Alzheimer's disease spectrum.".Brain imaging and behavior 15..2(2021)
