机构:[1]Institude of Geriatrics, Xiyuan Hospital China Academy of Chinese Medical Sciences Beijing 100091, P. R. China[2]Traditional Chinese Medicine Department Xuanwu Hospital Capital Medical University Beijing 100053, P. R. China首都医科大学宣武医院中医科
Cognitive impairment (CI) refers to the dysfunction of memory, language, visual space, execution, calculation, understanding, and judgment in one or more aspects. With global aging, CI will become prevalent worldwide. At present, there is no effective cure for CI. However, Nobel laureate Tu Youyou's research on artemisinin has inspired Chinese researchers to focus on traditional Chinese herbs (TCHs) for the treatment of CI. Traditional Chinese Medicine (TCM) has led to a theory for an independent CI system. The pathogenesis of such impairment involves deficiency, phlegm, and stagnation and involves a range of organs, including the brain, kidneys, heart, liver, and spleen. Our current understanding of the etiology and pathogenesis of this condition has led to the realization that TCHs can improve cognitive dysfunction. Clinical research has shown that TCHs can improve the neuropsychological scale score of patients, the TCM symptom score, and the patient's quality of life. Research has also suggested that TCHs can retard A
β
deposits and tauopathy, regulate the metabolism of cholinergic neurotransmitters, and so on. However, due to their complexity, little is known of the safety and efficacy of TCHs in patients with CI. It is likely that we will be able to identify the precise mechanisms associated with the action of TCHs in such patients due to the integration of multiple technologies. This paper summarizes the pharmacokinetics, curative effect, and mechanisms of action of traditional Chinese herbs in order to provide a scientific basis for the improvement of cognitive dysfunction by TCHs.
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外文
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中科院(CAS)分区:
出版当年[2019]版:
大类|3 区医学
小类|2 区全科医学与补充医学3 区医学:内科
最新[2023]版:
大类|2 区医学
小类|2 区全科医学与补充医学2 区医学:内科
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出版当年[2018]版:
Q1INTEGRATIVE & COMPLEMENTARY MEDICINEQ1MEDICINE, GENERAL & INTERNAL
最新[2023]版:
Q1MEDICINE, GENERAL & INTERNALQ1INTEGRATIVE & COMPLEMENTARY MEDICINE
第一作者机构:[1]Institude of Geriatrics, Xiyuan Hospital China Academy of Chinese Medical Sciences Beijing 100091, P. R. China
通讯作者:
通讯机构:[*1]Institude of Geriatrics, Xiyuan Hospital, China Academy of Chinese Medical Sciences, 1 Xiyuan Playground, Haidian District, Beijing 100091, P. R. China.
推荐引用方式(GB/T 7714):
Pei Hui,Ma Lina,Cao Yu,et al.Traditional Chinese Medicine for Alzheimer's Disease and Other Cognitive Impairment: A Review.[J].AMERICAN JOURNAL OF CHINESE MEDICINE.2020,48(3):487-511.doi:10.1142/S0192415X20500251.
APA:
Pei Hui,Ma Lina,Cao Yu,Wang Feixue,Li Zehui...&Li Hao.(2020).Traditional Chinese Medicine for Alzheimer's Disease and Other Cognitive Impairment: A Review..AMERICAN JOURNAL OF CHINESE MEDICINE,48,(3)
MLA:
Pei Hui,et al."Traditional Chinese Medicine for Alzheimer's Disease and Other Cognitive Impairment: A Review.".AMERICAN JOURNAL OF CHINESE MEDICINE 48..3(2020):487-511