机构：[1]Department of Neurobiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China首都医科大学宣武医院[2]Laboratory of Neuroscience, Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541001, China[3]Clinical Center for Parkinson’s Disease, Capital Medical University, Beijing 100069, China[4]Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Beijing Key Laboratory for Parkinson’s Disease, Parkinson Disease Center of Beijing Institute for Brain Disorders, Beijing 100053, China[5]National Clinical Research Center for Geriatric Disorders, Beijing 100053, China
Alpha-synucleinopathies (α-synucleinop-athies) are a diverse group of neurodegenerative diseases comprising Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Al-though in all these diseases there exist abnormal accumu-lation of alpha-synuclein (α-syn) aggregates in nerve tis-sues, the pathological lesions formed by α-syn aggregates and their cellular locations are quite different. In PD and DLB, the hallmark pathological lesions are Lewy bodies (LBs) and Lewy neurites (LNs), which are localized in the neuronal somata and processes. In MSA, the characteris-tic pathologic structures are glial cytoplasmic inclusions, which are deposited in the cytoplasm of oligodendrocytes. The fact that PD and MSA have distinct pathological α-syn lesions suggest that different mechanisms play a role in the pathogenesis of the two diseases. In this review article, we compare the clinical manifestations and pathological fea-tures of PD and MSA, the two common synucleinopathies, and discuss the potential mechanisms for the formation of α-syn aggregates and their pathologic roles in PD and MSA.
基金：
the authors are supported by grants
from Natural Science Foundation of China (81671244,
81371200, and 81401042), a special fund from Key
Laboratory of Neurodegenerative Disease, Ministry
of Education (PXM2019_026283_000002), Beijing
Municipal Science and Technology Commission
(Z161100005116011, Z171100000117013), and Beijing
Municipal commission of Health and Family Planning
(PXM2017_026283_000002).
语种：
外文
第一作者：
第一作者机构：[1]Department of Neurobiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
通讯作者：
推荐引用方式(GB/T 7714)：
Hanjiang Luo,Min Chen,Shun Yu.Pathogenic roles of alpha-synuclein in Parkinson's dis-ease and multiple system atrophy[J].Journal of Translational Neuroscience.2019,4(3):1-13.doi:10.3868/j.issn.2096-0689.2019.03.001.
APA：
Hanjiang Luo,Min Chen&Shun Yu.(2019).Pathogenic roles of alpha-synuclein in Parkinson's dis-ease and multiple system atrophy.Journal of Translational Neuroscience,4,(3)
MLA：
Hanjiang Luo,et al."Pathogenic roles of alpha-synuclein in Parkinson's dis-ease and multiple system atrophy".Journal of Translational Neuroscience 4..3(2019):1-13
