国家科技重大专项(2017ZX10104001-005-010, 2018ZX10201002-003-009)%国家自然科学基金(81971922)%北京市自然科学基金(7184208)%首都医科大学基础临床科研合作课题(17JL11)%The Key Technologies R&D Program of the National Ministry of Science(2017ZX10104001-005-010, 2018ZX10201002-003-009)%National Natural Science Foundation of China(81971922)%Beijing Natural Science Foundation(7184208)%Basic and Clinical Research Cooperation Project of Capital Medical University(17JL11)