机构：[a]Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA[b]Institute of Biomedical Engineering, Bogazici University, Istanbul 34684, Turkey[c]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China神经科系统神经内科首都医科大学宣武医院
It is crucial to reveal the variability between patients with epilepsy and healthy subjects to elucidate the underpinnings of the disease pathology. Herein, we assessed the inter-subject variability between patients with temporal lobe epilepsy (TLE) and healthy subjects in terms of estimating the functional connectivity using resting-state functional magnetic resonance (rs-fMRI) scans. According to inter-subject variability results between healthy and TLE population, the latter showed more variability mainly in frontoparietal control, default mode, dorsal/ventral attention, visual and somatomotor networks in line with the broad seizure onset and propagation pathway. As a result of 17-Network parcellation, a significant attenuation is observed in functional connectivity, mostly in bilateral frontoparietal control, somatomotor, default mode and ventral attention networks associated with the functional impairment in attention, long/short term memory, executive functioning. The results are in favor of the argument that the functional disruption in TLE spreads throughout the cortex beyond the temporal lobe with an implication of greater diversity in the TLE population.
基金：
TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [2214/A]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81571267]
第一作者机构：[a]Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA[b]Institute of Biomedical Engineering, Bogazici University, Istanbul 34684, Turkey
通讯作者：
推荐引用方式(GB/T 7714)：
Seda Nilgün Dumlu,Ahmet Ademoğlu,Wei Sun.Investigation of functional variability and connectivity in temporal lobe epilepsy: A resting state fMRI study[J].NEUROSCIENCE LETTERS.2020,733:doi:10.1016/j.neulet.2020.135076.
APA：
Seda Nilgün Dumlu,Ahmet Ademoğlu&Wei Sun.(2020).Investigation of functional variability and connectivity in temporal lobe epilepsy: A resting state fMRI study.NEUROSCIENCE LETTERS,733,
MLA：
Seda Nilgün Dumlu,et al."Investigation of functional variability and connectivity in temporal lobe epilepsy: A resting state fMRI study".NEUROSCIENCE LETTERS 733.(2020)
