机构：[1]Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing 100081, China.[2]School of Basic Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.[3]Advanced Innovation Center for Human Brain Protection, Capital Medical University, The National Clinical Research Center for Geriatric Disease, Xuanwu Hospital, Capital Medical University, Beijing, China.首都医科大学宣武医院国家老年疾病临床医学研究中心[4]ShandongCollaborative Innovation Center for Diagnosis & Treatment and Behavioral Interventions of mental disorders & Shandong Key Laboratory of Behavioral Medicine, Institute of Mental Health, Jining Medical University, Jining, Shandong 272067, China.[5]Beijing Advanced Innovation Center for Intelligent Robots and Systems, Beijing Institute of Technology, Beijing 100081, China.
The hippocampal CA3 contributes to spatial working memory (SWM), but which stage of SWM the CA3 neurons act on and whether the lateralization of CA3 function occurs in SWM is also unknown. Here, we reveal increased neural activity in both sample and choice phases of SWM. Left CA3 (LCA3) neurons show higher sensitivity in the choice phase during the correct versus error trials compared with right CA3 (RCA3) neurons. LCA3 initiates firing prior to RCA3 in the choice phase. Optogenetic suppression of pyramidal neurons in LCA3 disrupts SWM only in the choice phase. Furthermore, we discover that parvalbumin (PV) neurons, rather than cholinergic neurons in the medial septum (DB were cholinergic neurons), can project directly to unilateral CA3. Selective suppression of PV neurons in the MS projecting to LCA3 impairs SWM. The findings suggest that MSPV-LCA3 projection plays a crucial role in manipulating the lateralization of LCA3 in the retrieval of SWM. The CA3 region of the hippocampus is involved in spatial working memory. Here, the authors show that neurons in the left CA3 are more active in the choice phase of correct trials of spatial working memory than neurons in the right CA3, revealing lateralization of spatial working memory.
基金：
National Key R&D Program of China [2017YFE0117000]; National Key Research and Development Program of China [2018YFC1312302-3, 2018YFC0115400]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81870844, 81671268, 81701260]; Beijing Municipal Science and Technology CommissionBeijing Municipal Science & Technology Commission [Z191100010618004]; Xinglin Scholar of Shanghai University of Traditional Chinese Medicine [A1-U1820501040222]; Budgeted Research Project of Shanghai University of Traditional Chinese Medicine [18LK002]
第一作者机构：[1]Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing 100081, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Song Da,Wang Deheng,Yang Qinghu,et al.The lateralization of left hippocampal CA3 during the retrieval of spatial working memory[J].NATURE COMMUNICATIONS.2020,11(1):doi:10.1038/s41467-020-16698-4.
APA：
Song, Da,Wang, Deheng,Yang, Qinghu,Yan, Tianyi,Wang, Zhe...&Qing, Hong.(2020).The lateralization of left hippocampal CA3 during the retrieval of spatial working memory.NATURE COMMUNICATIONS,11,(1)
MLA：
Song, Da,et al."The lateralization of left hippocampal CA3 during the retrieval of spatial working memory".NATURE COMMUNICATIONS 11..1(2020)
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