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Remission of rheumatoid arthritis and potential determinants: a national multi-center cross-sectional survey

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机构: [1]Department of Rheumatology and Immunology, Peking University People’s Hospital, No.11 Xizhimen South Street, Beijing 100044, China [2]Department of Rheumatology and Immunology, Peking University Shougang Hospital, Beijing, China [3]Department of Rheumatology and Immunology, The Second Affiliated Hospital of Shanxi Medical University, Taiyuan, Shanxi, China [4]Department of Rheumatology and Immunology, The First Affiliated Hospital of BaotouMedical College, Baotou, InnerMongolia, China [5]Department of Rheumatology, China-Japan Friendship Hospital, Beijing, China [6]Department of Rheumatology and Immunology, Xijing Hospital of Fourth Military Medical University, Xi’an, Shaanxi, China [7]Department of Rheumatology and Immunology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China [8]Department of Rheumatology and Immunology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China [9]Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing, China [10]Department of Rheumatology and Immunology, The Affiliated Kailuan Hospital of North China CoalMedical University, Tangshan, Hebei, China [11]Department of Rheumatology and Immunology, Peking University First Hospital, Beijing, China [12]Department of Rheumatology and Immunology, Bethune International Peace Hospital, Shijiazhuang, Hebei, China [13]Department of Rheumatology and Immunology, Central Hospital of Handan City, Handan, Hebei, China [14]Department of Rheumatology and Immunology, Hebei People’s Hospital, Shijiazhuang, Hebei, China [15]Department of Rheumatology and Immunology, The People’s Hospital of Guangxi, Nanning, Guangxi, China [16]Department of Rheumatology and Immunology, Beijing Shunyi Hospital of China Medical University, Beijing, China [17]Department of Rheumatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China [18]Department of Rheumatology and Clinical Immunology, The 1st affiliated hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China [19]Department of Rheumatology and Immunology, Beijing Hospital, Beijing, China [20]Department of Rheumatology, Qilu Hospital of Shandong University, Jinan, Shandong, China [21]Department of Rheumatology and Immunology, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, Hebei, China [22]Department of Rheumatology and Immunology, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China [23]Department of Rheumatology and Immunology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China [24]Department of Infectious Diseases and Rheumatology, Tianjin Medical University General Hospital, Tianjin, China [25]Department of Rheumatology, Lanzhou University Second Hospital, Gansu, China [26]Department of Rheumatology and Immunology, Beijing Xuanwu Hospital, Beijing, China [27]Department of Rheumatology and Immunology, The Fifth Affiliated Hospital of Lanzhou University, Lanzhou, Gansu, China [28]Department of Rheumatology and Immunology, The 309th Hospital of Chinese People’s Liberation Army, Beijing, China [29]Department of Clinical Epidemiology, Peking University People’s Hospital, Beijing, China
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关键词: Cross-sectional study Remission Rheumatoid arthritis Risk factors

摘要:
The aim of this study is to investigate the remission rate of rheumatoid arthritis (RA) in China and identify its potential determinants. A multi-center cross-sectional study was conducted from July 2009 to January 2012. Data were collected by face-to-face interviews of the rheumatology outpatients in 28 tertiary hospitals in China. The remission rates were calculated in 486 RA patients according to different definitions of remission: the Disease Activity Score in 28 joints (DAS28), the Simplified Disease Activity Index (SDAI), the Clinical Disease Activity Index (CDAI), and the American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) Boolean definition. Potential determinants of RA remission were assessed by univariate and multivariate analyses. The remission rates of RA from this multi-center cohort were 8.6 % (DAS28), 8.4 % (SDAI), 8.2 % (CDAI), and 6.8 % (Boolean), respectively. Favorable factors associated with remission were: low Health Assessment Questionnaire (HAQ) score, absence of rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP), and treatment of methotrexate (MTX) and hydroxychloroquine (HCQ). Younger age was also predictive for the DAS28 and the Boolean remission. Multivariate analyses revealed a low HAQ score, the absence of anti-CCP, and the treatment with HCQ as independent determinants of remission. The clinical remission rate of RA patients was low in China. A low HAQ score, the absence of anti-CCP, and HCQ were significant independent determinants for RA remission.

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出版当年[2014]版:
大类 | 4 区 医学
小类 | 4 区 风湿病学
最新[2023]版:
大类 | 3 区 医学
小类 | 4 区 风湿病学
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出版当年[2013]版:
Q3 RHEUMATOLOGY
最新[2023]版:
Q2 RHEUMATOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2013版] 出版当年五年平均 出版前一年[2012版] 出版后一年[2014版]

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第一作者机构: [1]Department of Rheumatology and Immunology, Peking University People’s Hospital, No.11 Xizhimen South Street, Beijing 100044, China
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