机构：[1]Renal Division, Department of Medicine, Peking University First Hospital ,Peking University Institute of Nephrology ,Key Laboratory of Renal Disease,Ministry of Health of China ,Key Laboratory of Chronic Kidney DiseasePrevention and Treatment (Peking University), Ministry of Education, 8Xishiku Street, Xicheng District, Beijing 100034, China[2]Department ofNephrology, Qianfoshan Hospital, Shandong University, Jinan, China[3]Dialysisand Transplantation Centers, The Third Central Hospital, Tianjin, China[4]Department of Nephrology, Beijing ChaoYang Hospital, Beijing, China北京朝阳医院[5]Department of Nephrology, China-Japan Friendship Hospital, Beijing, China[6]Department of Nephrology, Peking University People’s Hospital, Beijing,China[7]Department of Nephrology, The General Hospital of Chinese People’sLiberation Army, Beijing, China[8]Department of Nephrology, The SecondHospital, Tianjin Medical University, Tianjin, China[9]The Blood PurificationCenter, Tianjin People’s Hospital, TianJin, China[10]Department of Nephrology,The Fourth Hospital, HeBei Medical University, ShiJia Zhuang, China河北医科大学第四医院[11]Department of Nephrology, The First Hospital, Dalian Medical University,Dalian, China大连医科大学附属第一医院[12]The Blood Purification Center, Beijing ChaoYang Hospital,Beijing, China北京朝阳医院[13]Department of Nephrology, TongRen Hospital, CapitalMedical University, Beijing, China首都医科大学附属同仁医院[14]Department of Nephrology, The CentralHospital of China Aerospace Corporation, Beijing, China[15]Department ofNephrology, The Beijing Shiji Tan Hospital, Beijing, China[16]Department ofNephrology, Dongzhi Men Hospital Affiliated to Beijing University of ChineseMedicine, Beijing, China[17]Department of Nephrology, Beijing Hospital,Beijing, China[18]Department of Nephrology, Xuanwu Hospital, CapitalMedical University, Beijing, China内科系统肾科首都医科大学宣武医院
Background: Family members of patients with end stage renal disease were reported to have an increased prevalence of chronic kidney disease (CKD). However, studies differentiated genetic and non-genetic family members are limited. We sought to investigate the prevalence of CKD among fist-degree relatives and spouses of dialysis patients in China. Methods: Seventeen dialysis facilities from 4 cities of China including 1062 first-degree relatives and 450 spouses of dialysis patients were enrolled. Sex-and age-matched controls were randomly selected from a representative sample of general population in Beijing. CKD was defined as decreased estimated glomerular (eGFR < 60 mL/min/1.73 m(2)) or albuminuria. Results: The prevalence of eGFR less than 60 mL/min/1.73 m(2), albuminuria and the overall prevalence of CKD in dialysis spouses were compared with their counterpart controls, which was 3.8% vs. 7.8% (P < 0.01), 16.8% vs. 14.6% (P = 0.29) and 18.4% vs. 19.8% (P = 0.61), respectively. The prevalence of eGFR less than 60 mL/min/1.73 m(2), albuminuria and the overall prevalence of CKD in dialysis relatives were also compared with their counterpart controls, which was 1.5% vs. 2.4% (P = 0.12), 14.4% vs. 8.4% (P < 0.01) and 14.6% vs. 10.5% (P < 0.01), respectively. Multivariable Logistic regression analysis indicated that being spouses of dialysis patients is negatively associated with presence of low eGFR, and being relatives of dialysis patients is positively associated with presence of albuminuria. Conclusions: The association between being family members of dialysis patients and presence of CKD is different between first-degree relatives and spouses. The underlying mechanisms deserve further investigation.
基金：
Beijing Science and Technology Committee [09050704310902]; International Society of Nephrology Research Committee; China Health and Medical Development Foundation
第一作者机构：[1]Renal Division, Department of Medicine, Peking University First Hospital ,Peking University Institute of Nephrology ,Key Laboratory of Renal Disease,Ministry of Health of China ,Key Laboratory of Chronic Kidney DiseasePrevention and Treatment (Peking University), Ministry of Education, 8Xishiku Street, Xicheng District, Beijing 100034, China[2]Department ofNephrology, Qianfoshan Hospital, Shandong University, Jinan, China
通讯作者：
推荐引用方式(GB/T 7714)：
Xianglei Kong,Li Liu,Li Zuo,et al.Association between family members of dialysis patients and chronic kidney disease: a multicenter study in China[J].BMC NEPHROLOGY.2013,14:doi:10.1186/1471-2369-14-19.
APA：
Xianglei Kong,Li Liu,Li Zuo,Ping Yuan,Zhongxin Li...&Haiyan Wang.(2013).Association between family members of dialysis patients and chronic kidney disease: a multicenter study in China.BMC NEPHROLOGY,14,
MLA：
Xianglei Kong,et al."Association between family members of dialysis patients and chronic kidney disease: a multicenter study in China".BMC NEPHROLOGY 14.(2013)
