机构:[1]首都医科大学附属北京同仁医院神经外科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]首都医科大学附属北京同仁医院眼科中心北京市眼科学及视觉科学重点实验室首都医科大学附属北京同仁医院首都医科大学附属同仁医院[3]北京市眼科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[4]首都医科大学附属北京宣武医院眼科外科系统眼科首都医科大学宣武医院[5]中国中医科学院眼科医院眼科[7]首都医科大学附属北京天坛医院, 北京市神经外科研究所神经外科首都医科大学附属天坛医院[8]Institute of Medical Psychology, Medical Faculty, Otto-v.-Guericke University of Magdeburg
To determine the interdependence of intracranial pressure (ICP) and intraocular pressure (IOP) and how it affects optic nerve pressures, eight normal dogs were examined using pressure-sensing probes implanted into the left ventricle, lumbar cistern, optic nerve subarachnoid space in the left eye, and anterior chamber in the left eye. This allowed ICP, lumbar cistern pressure (LCP), optic nerve subarachnoid space pressure (ONSP) and IOP to be simultaneously recorded. After establishing baseline pressure levels, pressure changes that resulted from lowering ICP (via shunting cerebrospinal fluid (CSF) from the ventricle) were recorded. At baseline, all examined pressures were different (ICP>LCP>ONSP), but correlated (P<0.001). As ICP was lowered during CSF shunting, IOP also dropped in a parallel time course so that the trans-lamina cribrosa gradient (TLPG) remained stable (ICP-IOP dependent zone). However, once ICP fell below a critical breakpoint, ICP and IOP became uncoupled and TLPG changed as ICP declined (ICP-IOP independent zone). The optic nerve pressure gradient (ONPG) and trans-optic nerve pressure gradient (TOPG) increased linearly as ICP decreased through both the ICP-IOP dependent and independent zones. We conclude that ICP and IOP are coupled in a specific pressure range, but when ICP drops below a critical point, IOP and ICP become uncoupled and TLPG increases. When ICP drops, a rise in the ONPG and TOPG creates more pressure and reduces CSF flow around the optic nerve. This change may play a role in the development and progression of various ophthalmic and neurological diseases, including glaucoma.
基金:
国家自然科学基金(批准号:81271005,81300767);;北京市自然科学基金(批准号:7122038);;国家健康与医学发展基金;;北京同仁医院科研骨干基金资助(批准号:2015-YJJ-GGL-013);;BMBF network ERA-net Neuron“Restoration of Vision after Stroke(REVIS)”(批准号:BMBF01EW1210);;北京海聚计划资助;
侯若武,章征,杨迪亚,et al.Pressure balance and imbalance in the optic nerve chamber: The Beijing Intracranial and Intraocular Pressure (iCOP) Study[J].Scientia Sinica(Vitae).2016,46(12):1413-1422.doi:10.1007/s11427-016-5022-9.
APA:
侯若武,章征,杨迪亚,王怀洲,陈伟伟...&王宁利.(2016).Pressure balance and imbalance in the optic nerve chamber: The Beijing Intracranial and Intraocular Pressure (iCOP) Study.Scientia Sinica(Vitae),46,(12)
MLA:
侯若武,et al."Pressure balance and imbalance in the optic nerve chamber: The Beijing Intracranial and Intraocular Pressure (iCOP) Study".Scientia Sinica(Vitae) 46..12(2016):1413-1422