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Structural and functional brain alterations in patients with idiopathic rapid eye movement sleep behavior disorder

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收录情况： ◇ SCIE

作者：
Meijie Chen, [1] * ; Yuan Li, [1] ; Jie Chen, [1] ; Linlin Gao, [1] ; Junyan Sun, [1] ; Zhuqin Gu, [1,2,3] ; Tao Wu [1,2,3,4,*1] ; Piu Chan [1,2,3,4,5,*2] ;
机构： [1]Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Geriatrics, Beijing, China [2]Clinical Center for Parkinson’s Disease, Capital Medical University, Beijing, China [3]Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Beijing Key Laboratory for Parkinson’s Disease, Parkinson Disease Center of Beijing Institute for Brain Disorders, Beijing, China [4]National Clinical Research Center for Geriatric Disorders, Beijing, China [5]Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
出处：
DOI： 10.1016/j.neurad.2020.04.007
ISSN：

关键词： Grey matter Rapid eye movement sleep behavior disorder Resting-state functional MRI Voxel-based morphometry

摘要：
Objective: To investigate structural and functional alterations in patients with idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) compared with healthy controls. Methods: Twenty-seven patients with polysomnography-confirmed iRBD and 33 healthy subjects were recruited. All subjects underwent a 3-tesla structural and resting-state functional magnetic resonance imaging (fMRI) examination. Voxel-based morphometry (VBM) analysis was performed to assess grey matter alterations between groups. The amplitude of low-frequency fluctuations (ALFF) was calculated and then compared to measure differences in spontaneous brain activity. Correlations were performed to explore associations between imaging metrics and clinical characteristics in iRBD patients. Results: Compared with healthy controls, patients with iRBD had decreased grey matter volume in the frontal, temporal, parietal, occipital cortices as well as increased grey matter volume in cerebellum posterior lobe, putamen, and thalamus. Patients with iRBD also exhibited increased ALFF values in the right parahippocampal gyrus. Olfaction correlated with ALFF value changes in occipital cortices. Conclusions: Patients with iRBD had widespread decreases of grey matter volume. Increases of grey matter volume in cerebellum, putamen, and thalamus may suggest a compensatory effect, while the altered ALFF values in parahippocampal gyrus and occipital cortices may play a role in the underlying process of neurodegeneration in this disorder. © 2020 Elsevier Masson SAS

基金：
The study was supported by the National Key R&D Program of China , No. 2018YFC1312001 , 2017YFC0840105 ; Beijing Municipal Administration of Hospitals’ Mission Plan , Code: SML20150803 ; Beijing Municipal Science & Technology Commission No. Z171100000117013 .
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外文
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被引次数：
WOS：
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中科院(CAS)分区：
出版当年[2021]版：
大类 | 3 区 医学
小类 | 3 区 临床神经病学 3 区 神经成像 3 区 核医学
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 临床神经病学 3 区 核医学 4 区 神经成像
JCR分区：
出版当年[2020]版：
Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Q2 CLINICAL NEUROLOGY Q2 NEUROIMAGING
最新[2023]版：
Q2 CLINICAL NEUROLOGY Q2 NEUROIMAGING Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

影响因子： 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者机构： [1]Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Geriatrics, Beijing, China
通讯作者：
通讯机构： [*1]Xuanwu Hospital of Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing 100053, China [*2]Xuanwu Hospital of Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing 100053, China.
推荐引用方式(GB/T 7714)：
Meijie Chen ,Yuan Li ,Jie Chen ,et al.Structural and functional brain alterations in patients with idiopathic rapid eye movement sleep behavior disorder[J].JOURNAL OF NEURORADIOLOGY.2022,49(1):66-72.doi:10.1016/j.neurad.2020.04.007.
APA：
Meijie Chen,,Yuan Li,,Jie Chen,,Linlin Gao,,Junyan Sun,...&Piu Chan.(2022).Structural and functional brain alterations in patients with idiopathic rapid eye movement sleep behavior disorder.JOURNAL OF NEURORADIOLOGY,49,(1)
MLA：
Meijie Chen,,et al."Structural and functional brain alterations in patients with idiopathic rapid eye movement sleep behavior disorder".JOURNAL OF NEURORADIOLOGY 49..1(2022):66-72

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