机构：[1]Eye Hospital of China Academy of Chinese Medical Sciences, Beijing, China.[2]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China.首都医科大学附属北京同仁医院首都医科大学附属同仁医院[3]Department of Ophthalmology, Medical Faculty Mannheim of the RuprechtKarls-University Heidelberg, Germany.[4]Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.首都医科大学附属北京同仁医院首都医科大学附属同仁医院[5]Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.首都医科大学附属北京同仁医院首都医科大学附属同仁医院[6]Department of Neurosurgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.首都医科大学附属北京同仁医院首都医科大学附属同仁医院[7]Department of Ophthalmology, Xuan Wu Hospital, Capital Medical University, Beijing China.外科系统眼科首都医科大学宣武医院[8]Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.首都医科大学附属北京同仁医院首都医科大学附属同仁医院
Introduction: The orbital subarachnoid space surrounding the optic nerve is continuous with the circulation system for cerebrospinal fluid (CSF) and can be visualized by using magnetic resonance imaging (MRI). We hypothesized that the orbital subarachnoid space width (OSASW) is correlated with and can serve as a surrogate for intracranial pressure (ICP). Our aim was to develop a method for a noninvasive measurement of the intracranial CSF-pressure (CSF-P) based on MRI-assisted OSASW. Methods: The prospective observational comparative study included neurology patients who underwent lumbar CSF-P measurement and 3.0-Tesla orbital magnetic resonance imaging (MRI) for other clinical reasons. The width of the orbital subarachnoid space (OSASW) around the optic nerve was measured with MRI at 3, 9, and 15 mm behind the globe. The study population was randomly divided into a training group and a test group. After adjusting for body mass index (BMI) and mean arterial blood pressure (MABP), algorithms for the associations between CSF-P and OSASW were calculated in the training group. The algorithms were subsequently verified in the test group. Main outcome measures were the width of the orbital subarachnoid space (OSASW) and the lumbar cerebrospinal fluid pressure (CSF-P). Results: Seventy-two patients were included in the study. In the training group, the algorithms for the associations between CSF-P and OSASW were as follows: (a) CSF-P = 9.31 x OSASW (at 3 mm) + 0.48 x BMI + 0.14 x MABP-19.94; (b) CSF-P = 16.95 x OSASW (at 9 mm) + 0.39 x BMI + 0.14 x MABP-20.90; and (c) CSF-P = 17.54 x OSASW (at 15 mm) + 0.47 x BMI + 0.13 x MABP-21.52. Applying these algorithms in the independent test group, the measured lumbar CSF-P (13.6 +/- 5.1 mm Hg) did not differ significantly from the calculated MRI-derived CSF-P (OSASW at 3 mm: 12.7 +/- 4.2 mm Hg (P = 0.07); at 9 mm: 13.4 +/- 5.1 mm Hg (P = 0.35); and at 15 mm: 14.0 +/- 4.9 mm Hg (P = 0.87)). Intraclass correlation coefficients (ICCs) were higher for the CSF-P assessment based on OSASW at 9 mm and at 15 mm behind the globe (all ICCs, 0.87) than for OSASW measurements at 3 mm (ICC, 0.80). Conclusions: In patients with normal, moderately decreased or elevated ICP, MRI-assisted measurement of the OSASW appears to be useful for the noninvasive quantitative estimation of ICP, if BMI and MABP as contributing parameters are taken into account.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81271005]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7122038]; Award of Excellent Doctoral Dissertation of Beijing (Beijing YXBS) [PXM2010_014226_07_000061, PXM2011_014226_07_000114]
第一作者机构：[1]Eye Hospital of China Academy of Chinese Medical Sciences, Beijing, China.[2]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China.
共同第一作者：
通讯作者：
通讯机构：[2]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China.[8]Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
推荐引用方式(GB/T 7714)：
Xie Xiaobin,Zhang Xiaojun,Fu Jidi,et al.Noninvasive intracranial pressure estimation by orbital subarachnoid space measurement: the Beijing Intracranial and Intraocular Pressure (iCOP) study[J].CRITICAL CARE.2013,17(4):doi:10.1186/cc12841.
APA：
Xie, Xiaobin,Zhang, Xiaojun,Fu, Jidi,Wang, Huaizhou,Jonas, Jost B....&Wang, Ningli.(2013).Noninvasive intracranial pressure estimation by orbital subarachnoid space measurement: the Beijing Intracranial and Intraocular Pressure (iCOP) study.CRITICAL CARE,17,(4)
MLA：
Xie, Xiaobin,et al."Noninvasive intracranial pressure estimation by orbital subarachnoid space measurement: the Beijing Intracranial and Intraocular Pressure (iCOP) study".CRITICAL CARE 17..4(2013)
医学