机构：[1]Department of Obstetrics and Gynecology, Peking University People's Hospital, Bejjing, China[2]Department of Obstetrics and Gynecology, Chinese PL A General Hospital, Bejjing, China[3]Department of Obstetrics and Gynecology, Beijing Hospital, Bejjing, China[4]Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Beijing, China[5]Department of Obstetrics and Gynecology, Beijing Anzhen Hospital, Bejjing, China[6]Department of Obstetrics and Gynecology, Beijing Chaoyang Hospital, Beijing, China[7]Department of Obstetrics and Gynecology, Peking University Third Hospital, Bejjing, China[8]Department of Obstetrics and Gynecology, Beijing Maternity Hospital, Beijing, China[9]Department of Obstetrics and Gynecology, Bejing Xuanwu Hospital, Beijing, China外科系统妇产科首都医科大学宣武医院[10]Department of Obstetrics and Gynecology, Bejing Tongren Hospital, Beijing, China[11]Department of Obstetrics and Gynecology, Bejing Tiantan Hospital, Beijing, China[12]Department of Obstetrics and Gynecology, Beijing Fuxing Hospital, Beijing, China[13]Department of Obstetrics and Gynecology, Beiing Shijitan Hospital, Beiing, China[14]Department of Statistics, Peking University First Hospital, Beijing, China
To evaluate the efficacy of folate receptor-mediated tumor detection (FRD) for identifying high-grade intraepithelial squamous lesions (HSIL) in the triage of women who are positive for human papillomavirus (HPV), and those with cytology findings of atypical squamous cells of undetermined significance (ASCUS).
A secondary analysis of prospectively collected data from 1504 women who had abnormal results during primary cervical cancer screening at 13 hospitals in Beijing, China, between November 2014 and August 2015. The detection accuracy of FRD was evaluated among HPV-positive women and women with ASCUS referred for colposcopy examination.
Among 1338 women with HPV, the percentage coincidence with pathology findings was higher for FRD (66.67%) than for cytology of ASCUS or higher (51.49%). The rate of colposcopy referral for cytology and FRD as a triage tool was 969 (72.4%) and 736 (55.0%), respectively. Thus, 233 (17.4%) fewer women would be referred for colposcopy by FRD. Among 476 women with cytology of ASCUS, the percentage coincidence with pathology findings was higher for FRD (63.45%) than for HPV (35.9%).
FRD was found to be a promising triage tool for women who are HPV-positive and those with cytology findings of ASCUS.
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第一作者机构：[1]Department of Obstetrics and Gynecology, Peking University People's Hospital, Bejjing, China
共同第一作者：
通讯作者：
通讯机构：[*1]Obstetrics and Gynecology Department, Peking University People’s Hospital, No. 11, Xizhimen South Street, Xicheng District, 100044 Beijing, China
推荐引用方式(GB/T 7714)：
Zhao Yun,Li Mingzhu,Li Yali,et al.Evaluation of folate receptor-mediated tumor detection as a triage tool in cervical cancer screening.[J].INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS.2020,150(3):379-384.doi:10.1002/ijgo.13245.
APA：
Zhao Yun,Li Mingzhu,Li Yali,Lv Qiubo,Chen Fei...&Wei Lihui.(2020).Evaluation of folate receptor-mediated tumor detection as a triage tool in cervical cancer screening..INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS,150,(3)
MLA：
Zhao Yun,et al."Evaluation of folate receptor-mediated tumor detection as a triage tool in cervical cancer screening.".INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS 150..3(2020):379-384
