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Genome-wide R-loop Landscapes during Cell Differentiation and Reprogramming.

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收录情况： ◇ SCIE

作者：
Pengze Yan,[1,7] * ; Zunpeng Liu,[2,7] * ; Moshi Song,[1,7,8,12] ; Zeming Wu,[2,7] ; Wei Xu,[9] ; Kuan Li,[9] ; Qianzhao Ji,[1,7] ; Si Wang,[1,7,8] ; Xiaoqian Liu,[2,7] ; Kaowen Yan,[1,7,8] ; Concepcion Rodriguez Esteban,[11] ; Weimin Ci,[3,4,7,8] ; Juan Carlos Izpisua Belmonte,[11] ; Wei Xie,[10] ; Jie Ren,[3,4,7,8] ; Weiqi Zhang,[3,4,7,8] ; Qianwen Sun,[9] ; Jing Qu,[2,7,8] ; Guang-Hui Liu[1,5,6,7,8] ;
机构： [1]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [3]China National Center for Bioinformation, Beijing 100101, China [4]CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, School of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China [5]National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China [6]Beijing Institute for Brain Disorders, Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China [7]University of Chinese Academy of Sciences, Beijing 100049, China [8]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China [9]Tsinghua-Peking Joint Center for Life Sciences, Tsinghua University, Beijing 100084, China [10]Center for Stem Cell Biology and Regenerative Medicine, MOE Key Laboratory of Bioinformatics, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China [11]Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
出处：
DOI： 10.1016/j.celrep.2020.107870
ISSN：

摘要：
DNA:RNA hybrids play key roles in both physiological and disease states by regulating chromatin and genome organization. Their homeostasis during cell differentiation and cell plasticity remains elusive. Using an isogenic human stem cell platform, we systematically characterize R-loops, DNA methylation, histone modifications, and chromatin accessibility in pluripotent cells and their lineage-differentiated derivatives. We confirm that a portion of R-loops formed co-transcriptionally at pluripotency genes in pluripotent stem cells and at lineage-controlling genes in differentiated lineages. Notably, a subset of R-loops maintained after differentiation are associated with repressive chromatin marks on silent pluripotency genes and undesired lineage genes. Moreover, in reprogrammed pluripotent cells, cell-of-origin-specific R-loops are initially present but are resolved with serial passaging. Our analysis suggests a multifaceted role of R-loops in cell fate determination that may serve as an additional layer of modulation on cell fate memory and cell plasticity. Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.

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外文
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中科院(CAS)分区：
出版当年[2019]版：
大类 | 1 区 生物
小类 | 2 区 细胞生物学
最新[2023]版：
大类 | 1 区 生物学
小类 | 2 区 细胞生物学
JCR分区：
出版当年[2018]版：
Q1 CELL BIOLOGY
最新[2023]版：
Q1 CELL BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

第一作者：
第一作者机构： [1]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [7]University of Chinese Academy of Sciences, Beijing 100049, China
共同第一作者：
通讯作者：
通讯机构： [1]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [3]China National Center for Bioinformation, Beijing 100101, China [4]CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, School of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China [5]National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China [6]Beijing Institute for Brain Disorders, Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China [7]University of Chinese Academy of Sciences, Beijing 100049, China [8]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China [9]Tsinghua-Peking Joint Center for Life Sciences, Tsinghua University, Beijing 100084, China
推荐引用方式(GB/T 7714)：
Pengze Yan ,Zunpeng Liu ,Moshi Song ,et al.Genome-wide R-loop Landscapes during Cell Differentiation and Reprogramming.[J].CELL REPORTS.2020,32(1):doi:10.1016/j.celrep.2020.107870.
APA：
Pengze Yan,,Zunpeng Liu,,Moshi Song,,Zeming Wu,,Wei Xu,...&Guang-Hui Liu.(2020).Genome-wide R-loop Landscapes during Cell Differentiation and Reprogramming..CELL REPORTS,32,(1)
MLA：
Pengze Yan,,et al."Genome-wide R-loop Landscapes during Cell Differentiation and Reprogramming.".CELL REPORTS 32..1(2020)

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