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Enolase-phosphatase 1 acts as an oncogenic driver in glioma.

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收录情况： ◇ SCIE ◇ 预警期刊

作者：

机构： [1]Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Department of Neurosurgery, Tianjin Neurosurgical Institute, Tianjin HuanhuHospital, Tianjin, China [2]State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, China [3]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China [4]Department of Gastroenterology, Tianjin Nankai Hospital, Tianjin, China [5]Tianjin Key Laboratory of Injuries, Variations, and Regeneration of Nervous System, Department of Neurosurgery, Tianjin Neurological Institute, General Hospital,Tianjin Medical University, Tianjin, China [6]Department of Hepatic Biliary Pancreatic Surgery, Cancer Hospital Affiliated to Zhengzhou University, Zhengzhou, China [7]Department of Biological Sciences, Virginia Tech, Blacksburg, Virginia [8]Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin–Madison, Madison, Wisconsin [9]Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Department of Medical Imaging, Tianjin Neurosurgical Institute, Tianjin HuanhuHospital, Tianjin, China

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关键词： AKT ENOPH1 glioma GSEA RNA‐seq

摘要：

Enolase-phosphatase 1 (ENOPH1), a newly identified enzyme involved in l-methionine biosynthesis, is associated with anxiety and depression. In this study, ENOPH1 was found to play a crucial role in promoting the proliferation and migration of glioma cells. Among high-grade glioma patients, the overall survival of the group showing high ENOPH1 expression was shorter than that of the group showing low ENOPH1 expression. ENOPH1 knockdown inhibited glioma cell proliferation and migration. In parallel, ENOPH1 knockdown suppressed tumor growth capacity and prolonged survival in an orthotopic glioma model. Mechanistically, we found that ENOPH1 activates the PI3K/AKT/mTOR signaling pathway by regulating THEM4. In conclusion, ENOPH1 is an important mediator that promotes glioma cell proliferation and migration.

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出版当年[2020]版：

大类 | 2 区生物

小类 | 2 区生理学 3 区细胞生物学

最新[2025]版：

大类 | 3 区生物学

小类 | 3 区细胞生物学 3 区生理学

JCR分区：

出版当年[2019]版：

Q1 PHYSIOLOGY Q2 CELL BIOLOGY

最新[2024]版：

Q1 PHYSIOLOGY Q2 CELL BIOLOGY

影响因子： 4 最新[2024版] 4.9 最新五年平均 5.546 出版当年[2019版] 4.834 出版当年五年平均 4.522 出版前一年[2018版] 6.384 出版后一年[2020版]

第一作者：

第一作者机构： [1]Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Department of Neurosurgery, Tianjin Neurosurgical Institute, Tianjin HuanhuHospital, Tianjin, China [2]State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, China

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通讯作者：

通讯机构： [*1]Department of Biological Sciences, Virginia Tech, No. 155 Otey Street, Blacksburg, VA 24061. [*2]Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Department of Medical Imaging, Tianjin Neurosurgical Institute, Tianjin Huanhu Hospital, No. 6 Jizhao Road, 300350 Tianjin, China. [*3]Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Department of Neurosurgery, Tianjin Neurosurgical Institute, Tianjin Huanhu Hospital, No. 6 Jizhao Road, 300350 Tianjin, China.

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