机构：[1]Cell Therapy Center, Beijing Institute of Geriatrics, Xuanwu Hospital Capital Medical University, National Clinical Research Center for Geriatric Diseases, And Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Beijing 100053, China内科系统科技平台老年医学科神经变性病教育部重点实验室细胞生物学研究室北京市老年病医疗研究中心国家老年疾病临床医学研究中心[2]Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing 100069, China[3]Center of Parkinson's Disease, Beijing Institute for Brain Disorders, Beijing 100069, China[4]Department of Neurology and Neuroscience Center, First Hospital of Jilin University, Changchun, Jilin Province, China
Mesenchymal stem/stromal cells (MSCs) are multipotent stem cells that can be derived from various tissues. Due to their regenerative and immunomodulatory properties, MSCs have been extensively researched and tested for treatment of different diseases/indications. One mechanism that MSCs exert functions is through the transfer of mitochondria, a key player involved in many biological processes in health and disease. Mitochondria transfer is bidirectional and has an impact on both donor and recipient cells. In this review, we discussed how MSC-mediated mitochondrial transfer may affect cellular metabolism, survival, proliferation, and differentiation; how this process influences inflammatory processes; and what is the molecular machinery that mediates mitochondrial transfer. In the end, we summarized recent advances in preclinical research and clinical trials for the treatment of stroke and spinal cord injury, through application of MSCs and/or MSC-derived mitochondria.
第一作者机构：[1]Cell Therapy Center, Beijing Institute of Geriatrics, Xuanwu Hospital Capital Medical University, National Clinical Research Center for Geriatric Diseases, And Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Beijing 100053, China[2]Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing 100069, China[3]Center of Parkinson's Disease, Beijing Institute for Brain Disorders, Beijing 100069, China
共同第一作者：
通讯作者：
通讯机构：[1]Cell Therapy Center, Beijing Institute of Geriatrics, Xuanwu Hospital Capital Medical University, National Clinical Research Center for Geriatric Diseases, And Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Beijing 100053, China[2]Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing 100069, China[3]Center of Parkinson's Disease, Beijing Institute for Brain Disorders, Beijing 100069, China[4]Department of Neurology and Neuroscience Center, First Hospital of Jilin University, Changchun, Jilin Province, China
推荐引用方式(GB/T 7714)：
Deqiang Han,Xin Zheng,Xueyao Wang,et al.Mesenchymal Stem/Stromal Cell-Mediated Mitochondrial Transfer and the Therapeutic Potential in Treatment of Neurological Diseases[J].STEM CELLS INTERNATIONAL.2020,2020:doi:10.1155/2020/8838046.
APA：
Deqiang Han,Xin Zheng,Xueyao Wang,Tao Jin,Li Cui&Zhiguo Chen.(2020).Mesenchymal Stem/Stromal Cell-Mediated Mitochondrial Transfer and the Therapeutic Potential in Treatment of Neurological Diseases.STEM CELLS INTERNATIONAL,2020,
MLA：
Deqiang Han,et al."Mesenchymal Stem/Stromal Cell-Mediated Mitochondrial Transfer and the Therapeutic Potential in Treatment of Neurological Diseases".STEM CELLS INTERNATIONAL 2020.(2020)
