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Integrative Proteomic Characterization of Human Lung Adenocarcinoma

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收录情况： ◇ SCIE ◇ 自然指数

作者：
Xu, Jun-Yu[1] * ; Zhang, Chunchao[2] * ; Wang, Xiang[3] * ; Zhai, Linhui[1] * ; Ma, Yiming[4] * ; Mao, Yousheng[5] ; Qian, Kun[6] ; Sun, Changqing[7] ; Liu, Zhiwei[8] ; Jiang, Shangwen[1] ; Wang, Minghui[3] ; Feng, Lin[3] ; Zhao, Lei[1] ; Liu, Ping[1] ; Wang, Bo[4] ; Zhao, Xin[6] ; Xie, Hui[7] ; Yang, Xiaoyun[4] ; Zhao, Liyuan[4] ; Chang, Yafei[4] ; Jia, Jingya[4] ; Wang, Xijun[3] ; Zhang, Yimin[4] ; Wang, Yaru[3] ; Yang, Yikun[5] ; Wu, Zhixiang[1] ; Yang, Longhai[5] ; Liu, Bin[1] ; Zhao, Teng[6] ; Ren, Shengguo[9] ; Sun, Aihua[2] ; Zhao, Yang[2] ; Ying, Wantao[2] ; Wang, Fei[9] ; Wang, Guangshun[10] ; Zhang, Yi[6] ; Cheng, Shujun[3] ; Qin, Jun[2] ; Qian, Xiaohong[2] ; Wang, Yi[2] ; Li, Jing[4] ; He, Fuchu[2] ; Xiao, Ting[3] ; Tan, Minjia[1,8] ;
机构： [1]State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China [2]State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China [3]State Key Laboratory of Molecular Oncology, Department of Etiology and Carcinogenesis, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China [4]Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China [5]Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China [6]Department of Thoracic Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [7]Department of Oncology, Tianjin Baodi Hospital, Tianjin 301800, China [8]University of the Chinese Academy of Sciences, Beijing, China [9]Shanghai Key Laboratory of Intelligent Information Processing, School of Computer Science and Technology, Fudan University, Shanghai 200433, China [10]Department of Oncology, Baodi Clinical College of Tianjin Medical University, Tianjin 301800, China
出处：
DOI： 10.1016/j.cell.2020.05.043
ISSN：

摘要：
Genomic studies of lung adenocarcinoma (LUAD) have advanced our understanding of the disease's biology and accelerated targeted therapy. However, the proteomic characteristics of LUAD remain poorly understood. We carried out a comprehensive proteomics analysis of 103 cases of LUAD in Chinese patients. Integrative analysis of proteome, phosphoproteome, transcriptome, and whole-exome sequencing data revealed cancer-associated characteristics, such as tumor-associated protein variants, distinct proteomics features, and clinical outcomes in patients at an early stage or with EGFR and TP53 mutations. Proteome-based stratification of LUAD revealed three subtypes (S-I, S-II, and S-III) related to different clinical and molecular features. Further, we nominated potential drug targets and validated the plasma protein level of HSP 90 beta as a potential prognostic biomarker for LUAD in an independent cohort. Our integrative proteomics analysis enables a more comprehensive understanding of the molecular landscape of LUAD and offers an opportunity for more precise diagnosis and treatment.

基金：
National Basic Research Program of China (973 Program)National Basic Research Program of China [2014CBA02004]; Natural Science Foundation of ChinaNational Natural Science Foundation of China [81821005, 91753203, 81872888, 31901036, 31871329, 31700724]; Strategic Priority Research Program of the Chinese Academy of SciencesChinese Academy of Sciences [XDA12050406]; CAMS Innovation Fund for Medical Sciences (CIFMS), China [2016-I2M-1-001]; National Key Research and Development Program of China [2017YFC0908401]; Shanghai Sailing Program [19YF1457700]; Innovative Research Team of High-Level Local Universities in Shanghai [SSMU-ZDCX20181202]; K. C. Wong Education Foundation; SA-SIBS Scholarship Program
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外文
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中科院(CAS)分区：
出版当年[2019]版：
大类 | 1 区 生物
小类 | 1 区 生化与分子生物学 1 区 细胞生物学
最新[2023]版：
大类 | 1 区 生物学
小类 | 1 区 生化与分子生物学 1 区 细胞生物学
JCR分区：
出版当年[2018]版：
Q1 CELL BIOLOGY Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
最新[2023]版：
Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 CELL BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

第一作者：
第一作者机构： [1]State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Xu Jun-Yu,Zhang Chunchao,Wang Xiang,et al.Integrative Proteomic Characterization of Human Lung Adenocarcinoma[J].CELL.2020,182(1):245-+.doi:10.1016/j.cell.2020.05.043.
APA：
Xu, Jun-Yu,Zhang, Chunchao,Wang, Xiang,Zhai, Linhui,Ma, Yiming...&Tan, Minjia.(2020).Integrative Proteomic Characterization of Human Lung Adenocarcinoma.CELL,182,(1)
MLA：
Xu, Jun-Yu,et al."Integrative Proteomic Characterization of Human Lung Adenocarcinoma".CELL 182..1(2020):245-+

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