机构：[a]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China神经科系统神经外科首都医科大学宣武医院[b]Department of Neurology, Affiliated Hospital of Nantong University, Nantong, China[c]Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI, USA[d]Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China
It has been established that poor outcomes in ischemic stroke patients are associated with the post-reperfusion inflammatory response and up-regulation of TLR4. Therefore, suppression of the TLR4 signaling pathway constitutes a potential neuroprotective therapeutic strategy. Schisandrin B, a compound extracted fromSchisandra chinensis, has been shown to possess anti-inflammatory and neuroprotective properties. However, the mechanism remains unclear. In the present study, the therapeutic effect of schisandrin B was assessed following cerebral ischemia and reperfusion (I/R) injury in a model of middle cerebral artery occlusion and reperfusion (MCAO/R) in rats. The effects of schisandrin B were investigated with particular emphasis on TLR4 signal transduction and on the inflammatory response. Schisandrin B treatment conferred significant protection against MCAO/R injury, as evidenced by decreases in infarct volume, neurological score, and the number of apoptotic neurons and inflammatory signaling molecules.
基金：
This work was supported by the National College Students
Innovation and Entrepreneurship Training Program (CN)
[2018153]; Nantong science and technology plan project
[MSZ18102].
第一作者机构：[a]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China[b]Department of Neurology, Affiliated Hospital of Nantong University, Nantong, China
通讯作者：
通讯机构：[*1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Xingjuan Fan,Kenneth Elkin,Yunwei Shi,et al.Schisandrin B improves cerebral ischemia and reduces reperfusion injury in rats through TLR4/NF-kappa B signaling pathway inhibition[J].NEUROLOGICAL RESEARCH.2020,42(8):693-702.doi:10.1080/01616412.2020.1782079.
APA：
Xingjuan Fan,Kenneth Elkin,Yunwei Shi,Zhihong Zhang,Yaqin Cheng...&Xunming Ji.(2020).Schisandrin B improves cerebral ischemia and reduces reperfusion injury in rats through TLR4/NF-kappa B signaling pathway inhibition.NEUROLOGICAL RESEARCH,42,(8)
MLA：
Xingjuan Fan,et al."Schisandrin B improves cerebral ischemia and reduces reperfusion injury in rats through TLR4/NF-kappa B signaling pathway inhibition".NEUROLOGICAL RESEARCH 42..8(2020):693-702
