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Biocompatibility evaluation of heparin-conjugated poly(ε-caprolactone) scaffolds in a rat subcutaneous implantation model

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收录情况： ◇ SCIE ◇ EI

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机构： [1]Department of Vascular Surgery, Xuan Wu Hospital and Institute of Vascular Surgery, Capital Medical University, 100053 Beijing, China [2]School of Materials Science & Engineering, Beijing Institute of Technology, 100081 Beijing, China

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Vascular grafts prepared from synthetic polymers have serious shortcomings that can be resolved by surface modification, such as by immobilizing heparin. In this study, the mechanical properties, biocompatibility, anticoagulation property, and water contact angle of two heparin-conjugated poly(ε-caprolactone) scaffolds (PCL-hexamethylendiamine-heparin, PCL-HMD-H. PCL-lysine-heparin, PCL-LYS-H) were compared to identify a preferred heparin conjugation method. An evaluation of the subcutaneous tissue biocompatibility of the scaffolds demonstrated that PCL-HMD-H had better endothelial cell proliferation than the PCL-LYS-H and was therefore a promising scaffold candidate for use in vascular tissue-engineering. [Figure not available: see fulltext.] © 2020, Springer Science+Business Media, LLC, part of Springer Nature.

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出版当年[2019]版：

大类 | 3 区工程技术

小类 | 3 区工程：生物医学 4 区材料科学：生物材料

最新[2023]版：

大类 | 3 区医学

小类 | 3 区工程：生物医学 4 区材料科学：生物材料

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出版当年[2018]版：

Q2 ENGINEERING, BIOMEDICAL Q3 MATERIALS SCIENCE, BIOMATERIALS

最新[2023]版：

Q2 ENGINEERING, BIOMEDICAL Q2 MATERIALS SCIENCE, BIOMATERIALS

影响因子： 4.2 最新[2023版] 4.2 最新五年平均 2.467 出版当年[2018版] 2.688 出版当年五年平均 2.448 出版前一年[2017版] 2.489 出版后一年[2019版]

第一作者：

第一作者机构： [1]Department of Vascular Surgery, Xuan Wu Hospital and Institute of Vascular Surgery, Capital Medical University, 100053 Beijing, China

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