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Clinical characteristics and outcomes of critically ill patients with novel coronavirus infectious disease (COVID-19) in China: a retrospective multicenter study

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机构： [1]Jiangsu Provincial Key Laboratory of Critical Care Medicine, Departmentof Critical Care Medicine, Zhongda Hospital, School of Medicine, SoutheastUniversity, Nanjing 210009, Jiangsu, China [2]Department of Critical CareMedicine, Wuhan Jin-Yintan Hospital, Wuhan 430071, China [3]Departmentof Critical Care Medicine, Tongji Hospital, Tongji Medical College HuazhongUniversity of Science and Technology, Wuhan 430030, China [4]Departmentof Critical Care Medicine, Union Hospital, Tongji Medical College HuazhongUniversity of Science and Technology, Wuhan 430022, China [5]Departmentof Infection Disease, Wuhan Pulmonary Hospital, Wuhan, China [6]Departmentof Critical Care Medicine, Shenzhen Third Hospital, Shenzhen, China [7]Department of Critical Care Medicine, Huangshi Hospital of ChineseMedicine, Huangshi 435000, China [8]Department of Critical Care Medicine,Huangshi Central Hospital, Huangshi 435000, China [9]Department of Respiratoryand Critical Care Medicine, Beijing Institute of Respiratory Medicine,Beijing Chao‑Yang Hospital, Capital Medical University, Beijing 100020, China [10]Department of Critical Care Medicine, Xuanwu Hospital, Capital MedicalUniversity, Beijing 100053, China [11]Emergency Department, The 900th Hospitalof Joint Service Corps of Chinese PLA, Fuzhou 350025, China [12]Departmentof Critical Care Medicine, Zhongshan Hospital, Fudan University,Shanghai 200032, China [13]Department of Critical Care Medicine, GuangzhouInstitute of Respiratory Health, The First Affiliated Hospital of GuangzhouMedical University, Guangzhou 510120, China [14]Department of Critical CareMedicine, The First Affiliated Hospital, College of Medicine, Zhejiang University,Hangzhou 310003, China [15]Department of Critical Care Medicine, NorthernJiangsu People’s Hospital, Clinical Medical School, Yangzhou University, Yangzhou225001, China [16]Medical ICU, Peking Union Medical College Hospital,Peking Union Medical College and, Chinese Academy of Medical Sciences,Beijing 100730, China

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关键词： COVID-19 Critically ill Organ failure Mortality

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Purpose An ongoing outbreak of coronavirus disease 2019 (COVID-19) emerged in Wuhan since December 2019 and spread globally. However, information about critically ill patients with COVID-19 is still limited. We aimed to describe the clinical characteristics and outcomes of critically ill patients with COVID-19 and figure out the risk factors of mortality. Methods We extracted data retrospectively regarding 733 critically ill adult patients with laboratory-confirmed COVID-19 from 19 hospitals in China through January 1 to February 29, 2020. Demographic data, symptoms, laboratory values, comorbidities, treatments, and clinical outcomes were collected. The primary outcome was 28-day mortality. Data were compared between survivors and non-survivors. Results Of the 733 patients included in the study, the median (IQR) age was 65 (56-73) years and 256 (34.9%) were female. Among these patients, the median (IQR) APACHE II score was 10 (7 to 14) and 28-day mortality was 53.8%. Respiratory failure was the most common organ failure (597 [81.5%]), followed by shock (20%), thrombocytopenia (18.8%), central nervous system (8.6%) and renal dysfunction (8%). Multivariate Cox regression analysis showed that older age, malignancies, high APACHE II score, highd-dimer level, low PaO2/FiO(2)level, high creatinine level, high hscTnI level and low albumin level were independent risk factors of 28-day mortality in critically ill patients with COVID-19. Conclusion In this case series of critically ill patients with COVID-19 who were admitted into the ICU, more than half patients died at day 28. The higher percentage of organ failure in these patients indicated a significant demand for critical care resources.

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出版当年[2019]版：

大类 | 1 区

医学

小类 | 1 区危重病医学

最新[2023]版：

大类 | 1 区

医学

小类 | 1 区危重病医学

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Q1 CRITICAL CARE MEDICINE

最新[2023]版：

Q1 CRITICAL CARE MEDICINE

影响因子： 29.6 最新[2023版] 24.7 最新五年平均 18.967 出版当年[2018版] 13.009 出版当年五年平均 15.008 出版前一年[2017版] 17.679 出版后一年[2019版]

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第一作者机构： [1]Jiangsu Provincial Key Laboratory of Critical Care Medicine, Departmentof Critical Care Medicine, Zhongda Hospital, School of Medicine, SoutheastUniversity, Nanjing 210009, Jiangsu, China

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Clinical characteristics and outcomes of critically ill patients with novel coronavirus infectious disease (COVID-19) in China: a retrospective multicenter study