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Altered coupling between resting-state glucose metabolism and functional activity in epilepsy (Open Access)

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收录情况： ◇ SCIE

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机构： [1]Department of Nuclear Medicine, Xuanwu Hospital Capital Medical University, Beijing, China [2]Department of Radiology, Xuanwu Hospital Capital Medical University, Beijing, China [3]Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China [4]Department of Neurosurgery, Beijing Haidian Section of Peking University Third Hospital, Beijing, China [5]Department of Functional Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, China [6]GE Healthcare, Beijing, China [7]Division of Nuclear Technology and Applications, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China [8]Beijing Engineering Research Center of Radiographic Techniques and Equipment, Beijing, China [9]CAS Centre for Excellence in Brain Science and Intelligent Technology, Shanghai, China [10]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China

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Objective: Altered functional activities and hypometabolism have been found in medial temporal lobe epilepsy patients with hippocampal sclerosis (mTLE-HS). Hybrid PET/MR scanners provide opportunities to explore the relationship between resting-state energy consumption and functional activities, but whether repeated seizures disturb the bioenergetic coupling and its relationship with seizure outcomes remain unknown. Methods: 18F-FDG PET and resting-state functional MRI (rs-fMRI) scans were performed with hybrid PET/MR in 26 patients with mTLE-HS and in healthy controls. Energy consumption was quantified by 18F-FDG standardized uptake value ratio(SUVR) relative to cerebellum. Spontaneous neural activities were estimated using regional homogeneity (ReHo), fractional amplitude of low frequency fluctuations (fALFF) from rs-fMRI. Between-group differences in SUVR and rs-fMRI derived metrics were evaluated by two-sample t test. Voxel-wise spatial correlations were explored between SUVR and ReHo, fALFF across gray matter and compared between groups. Furthermore, the relationships between altered fALFF/SUVR and ReHo/SUVR coupling and surgical outcomes were evaluated. Results: Both the patients and healthy controls showed significant positive correlations between SUVR and rs-fMRI metrics. Spatial correlations between SUVR and fMRI-derived metrics across gray matter were significantly higher in patients with mTLE-HS compared with healthy controls (fALFF/SUVR, P < 0.001; ReHo/SUVR, P = 0.022). Higher fALFF/SUVR couplings were found in patients who had Engel class IA after surgery than all other (P = 0.025), while altered ReHo/SUVR couplings (P = 0.097) were not. Conclusion: These findings demonstrated altered bioenergetic coupling across gray matter and its relationship with seizure outcomes, which may provide novel insights into pathogenesis of mTLE-HS and potential biomarkers for epilepsy surgery planning. © 2020 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association

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基金编号： grant numbers 2016YFC0103909

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出版当年[2019]版：

大类 | 2 区医学

小类 | 2 区临床神经病学 2 区神经科学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区临床神经病学 2 区神经科学

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出版当年[2018]版：

Q1 CLINICAL NEUROLOGY Q1 NEUROSCIENCES

最新[2023]版：

Q1 CLINICAL NEUROLOGY Q1 NEUROSCIENCES

影响因子： 4.4 最新[2023版] 5.1 最新五年平均 4.656 出版当年[2018版] 4.489 出版当年五年平均 4.649 出版前一年[2017版] 3.66 出版后一年[2019版]

第一作者：

第一作者机构： [1]Department of Nuclear Medicine, Xuanwu Hospital Capital Medical University, Beijing, China

通讯作者：

通讯机构： [1]Department of Nuclear Medicine, Xuanwu Hospital Capital Medical University, Beijing, China [2]Department of Radiology, Xuanwu Hospital Capital Medical University, Beijing, China [3]Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China [10]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China [*1]No.45 Changchun Street, Xicheng District, 100053, Beijing, China [*2]No.45 Changchun Street, Xicheng District, 100053, Beijing, China.

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