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Altered cortical gray matter volume and functional connectivity after transcutaneous spinal cord direct current stimulation in idiopathic restless legs syndrome

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收录情况： ◇ SCIE

作者：
Li Wang [a, b, c] * ; Chunyan Liu [a, b, c] ; Yue Hou [a, b, c] ; Shuqin Zhan [a, b, c] ; Zhang Zhang [a, b, c] ; Jiaojian Wang [d] ; Yuping Wang [a, b, c,*1] ;
机构： [a]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China [b]Beijing Key Laboratory of Neuromodulation, Beijing, China [c]Beijing Institute of Brain Disorders, Capital Medical University, China [d]School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China
出处：
DOI： 10.1016/j.sleep.2020.07.026
ISSN：

关键词： Functional connectivity Gray matter volume Restless legs syndrome Transcutaneous spinal cord direct current stimulation

摘要：
Objective: To explore the neurophysiological mechanism of clinically effective transcutaneous spinal cord direct current stimulation (tsDCS) on idiopathic restless legs syndrome (RLS), structural magnetic resonance imaging (sMRI), and resting-state functional MRI (rs-fMRI) were applied to reveal the structural and functional changes in idiopathic RLS patients after tsDCS. Methods: Thirty idiopathic RLS patients and 20 gender- and age-matched healthy controls (HC) were enrolled. All patients were randomly divided into anodal treatment group and sham treatment group and were treated with tsDCS for 2 weeks. The international RLS Rating Scale (IRLS-RS) and Pittsburgh Sleep Quality Index (PSQI) were used to evaluate the severity of RLS and sleep quality respectively. The sMRI and rs-fMRI data of anodal treatment group and HC were collected. Voxel-based morphology (VBM) and resting-state functional connectivity analysis were used to assess the change of cortical gray matter volume (GMV) and corresponding functional connectivity (FC) respectively in anodal treatment group after tsDCS treatment. Results: Sham treatment group showed no significant change in IRLS-RS and PSQI scores after tsDCS, while significant decrease scores were observed in anodal treatment group, and the improvement sustained up to 2 weeks. Anodal treatment group showed significant regional decrease of GMV in bilateral cuneus compared to the HC. After tsDCS treatment, the GMV in the bilateral cuneus and left ventral post central gyrus (PoCG_L) decreased significantly. The FC between bilateral cuneus and left primary visual cortex (V1_L), and between right cuneus (Cune_R) and right lingual gyrus (LG_R) increased significantly after tsDCS, whereas the FC between PoCG_L and supplementary motor area (SMA) decreased significantly. The changed FC between PoCG_L and SMA, between Cune_R and V1_L were correlated with the changed IRLS-RS. Conclusion: Disturbance of sensorimotor network and visual processing network may be involved in the pathogenesis of RLS. tsDCS probably can regulate FC in the sensorimotor cortex and visual processing cortex to relieve the symptom of RLS. Continuous tsDCS may improve the symptoms of RLS patients for a long time. tsDCS probably could provide a potential non-pharmacologic treatment for idiopathic RLS patients. © 2020 Elsevier B.V.

基金：
This work was supported by the National Key R&D Program of China (Spinal Cord Stimulation), Grant No. 2016YFC0105605 .
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类 | 3 区 医学
小类 | 3 区 临床神经病学
最新[2023]版：
大类 | 2 区 医学
小类 | 2 区 临床神经病学
JCR分区：
出版当年[2018]版：
Q2 CLINICAL NEUROLOGY
最新[2023]版：
Q1 CLINICAL NEUROLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

第一作者：
第一作者机构： [a]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构： [a]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China [*1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
推荐引用方式(GB/T 7714)：
Li Wang,Chunyan Liu,Yue Hou,et al.Altered cortical gray matter volume and functional connectivity after transcutaneous spinal cord direct current stimulation in idiopathic restless legs syndrome[J].SLEEP MEDICINE.2020,74:254-261.doi:10.1016/j.sleep.2020.07.026.
APA：
Li Wang,Chunyan Liu,Yue Hou,Shuqin Zhan,Zhang Zhang...&Yuping Wang.(2020).Altered cortical gray matter volume and functional connectivity after transcutaneous spinal cord direct current stimulation in idiopathic restless legs syndrome.SLEEP MEDICINE,74,
MLA：
Li Wang,et al."Altered cortical gray matter volume and functional connectivity after transcutaneous spinal cord direct current stimulation in idiopathic restless legs syndrome".SLEEP MEDICINE 74.(2020):254-261

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