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Research on the Characteristics of Action Potentials and Local Field Potentials in Cortex of Parkinson's Disease Mode Monkey

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机构: [1]State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing 100190 China [2]University of Chinese Academy of Sciences, Beijing 100049, China. [3]Department of Neurobiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China. [4]Department of Neurobiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China and the Wincon TheraCells Biotechnologies Co., Ltd., Nanning 530002, China
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Parkinson's disease (PD) is characterized by excessively synchronized neural activity. In this paper, we recorded electrophysiological signals in Cortex of normal and PD mode monkey using homemade implantable microelectrode arrays (MEA), and analyzed the characteristics of action potentials (APs) and local field potentials (LFPs). Results showed that, comparing to normal monkey, the spike-firing activity of PD mode monkey could be divided into two stages: the continuous spike-firing stage and the burst spike-firing stage. The continuous spike-firing lasted for about 20s and oscillated at low frequency about 0.03Hz. APs fired in a burst mode between two continuous discharges. In the continuous spike-firing stage, the spike-firing activity was related to the ripple rhythm (100-200Hz) of LFPs with a coherence 0.86, while, in the burst spike-firing stage, it was related to the phase of theta rhythm (4-7 Hz). APs tended to discharge in the valley of theta rhythm (average peak phase is -10°).Clinical Relevance - This article can provide some references for the study of PD neuropathology. © 2020 IEEE.

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第一作者机构: [1]State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing 100190 China [2]University of Chinese Academy of Sciences, Beijing 100049, China.
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