机构：[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China,神经科系统神经内科首都医科大学宣武医院[2]Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China,[3]Department of China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China,科技平台中美神经科学研究所首都医科大学宣武医院[4]Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI, United States,[5]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China神经科系统神经外科首都医科大学宣武医院
Background:As an indispensable part of the cerebral venous system, the extracranial cerebrospinal venous system is not fully recognized. This study aimed to analyze the clinical classification and imaging characteristics of chronic cerebrospinal venous insufficiency (CCSVI) quantitatively. Methods:A total of 128 patients, who were diagnosed as CCSVI by jugular ultrasound and contrast-enhanced magnetic resonance venography (CE-MRV), were enrolled from May 2018 through May 2019. For the patients with possible extraluminal compression, computed tomography venography (CTV) was applied to estimate the degree of internal jugular venous stenosis (IJVS) and rank the vertebral venous collateral circulation. Results:The causes of extraluminal compression induced IJVS included osseous compression (78.95%), carotid artery (24.21%), sternocleidomastoid muscle (5.79%), swollen lymph node (1.05%), and unknown reasons (5.26%). The subtypes of non-compression CCSVI included the high jugular bulb (77.27%), fenestration of the internal jugular vein (IJV) (7.27%), internal jugular phlebectasia (2.73%), tortuous IJV (0.91%), IJV thrombosis (14.55%), and elongated venous valves with/without erythrocyte aggregation (13.64%). For extraluminal compression induced IJVS, the ratio of severe vertebral venous expansion was higher in the severe IJVS group than that in the mild IJVS group (p< 0.001). The IJVS degree was higher in the severe vertebral venous expansion group than in the mild vertebral venous expansion group (p< 0.001). Conclusions:A multimodal diagnostic system is necessary to improve the diagnostic accuracy of CCSVI. The vertebral venous system is an important collateral circulation for CCSVI, which may be a promising indicator for evaluating IJVS degree.
基金：
National Key R&D Program of China [2017YFC1308400]; National Natural Science FoundationNational Natural Science Foundation of China (NSFC) [81371289]; Project of Beijing Municipal Top Talent for HealthyWork of China [2014-2-015]
第一作者机构：[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China,[2]Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China,[3]Department of China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China,
通讯作者：
推荐引用方式(GB/T 7714)：
Wang Zhongao,Ding Jiayue,Bai Chaobo,et al.Clinical Classification and Collateral Circulation in Chronic Cerebrospinal Venous Insufficiency[J].FRONTIERS IN NEUROLOGY.2020,11:doi:10.3389/fneur.2020.00913.
APA：
Wang, Zhongao,Ding, Jiayue,Bai, Chaobo,Ding, Yuchuan,Ji, Xunming&Meng, Ran.(2020).Clinical Classification and Collateral Circulation in Chronic Cerebrospinal Venous Insufficiency.FRONTIERS IN NEUROLOGY,11,
MLA：
Wang, Zhongao,et al."Clinical Classification and Collateral Circulation in Chronic Cerebrospinal Venous Insufficiency".FRONTIERS IN NEUROLOGY 11.(2020)
