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Electrical stimulation of the endopiriform nucleus attenuates epilepsy in rats by network modulation.

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机构： [1]Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China [2]Neuroelectrophysiological Laboratory, Xuanwu Hospital, Capital Medical University, Beijing, China [3]Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China [4]Department of Electronic Engineering, Institute of Microelectronics, Tsinghua University, Beijing, China [5]College of Electrical and Control Engineering, North China University of Technology, Beijing, China [6]Department of Neurology, University of Minnesota, Minnesota [7]Center for Magnetic Resonance Research, University of Minnesota, Minnesota

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Neuromodulatory anterior thalamic deep brain stimulation (DBS) is an effective therapy for intractable epilepsy, but few patients achieve complete seizure control with thalamic DBS. Other stimulation sites may be considered for anti-seizure DBS. We investigated bilateral low-frequency stimulation of the endopiriform nuclei (LFS-EPN) to control seizures induced by intracortically implanted cobalt wire in rats. Chronic epilepsy was induced by cobalt wire implantation in the motor cortex unilaterally. Bipolar-stimulating electrodes were implanted into the EPN bilaterally. Continuous electroencephalography (EEG) was recorded using electrodes placed into bilateral motor cortex and hippocampus CA1 areas. Spontaneous seizures were monitored by long-term video-EEG, and behavioral seizures were classified based on the Racine scale. Continuous 1-Hz LFS-EPN began on the third day after electrode implantation and was controlled by a multi-channel stimulator. Stimulation continued until the rats had no seizures for three consecutive days. Compared with the control and sham stimulation groups, the LFS-EPN group experienced significantly fewer seizures per day and the mean Racine score of seizures was lower due to fewer generalized seizures. Ictal discharges at the epileptogenic site had significantly reduced theta band power in the LFS-EPN group compared to the other groups. Bilateral LFS-EPN attenuates cobalt wire-induced seizures in rats by modulating epileptic networks. Reduced ictal theta power of the EEG broadband spectrum at the lesion site may be associated with the anti-epileptogenic mechanism of LFS-EPN. Bilateral EPN DBS may have therapeutic applications in human partial epilepsies. © 2020 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.

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出版当年[2019]版：

大类 | 2 区医学

小类 | 2 区临床神经病学 2 区神经科学

最新[2023]版：

大类 | 2 区医学

小类 | 2 区临床神经病学 2 区神经科学

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出版当年[2018]版：

Q1 CLINICAL NEUROLOGY Q1 NEUROSCIENCES

最新[2023]版：

Q1 CLINICAL NEUROLOGY Q1 NEUROSCIENCES

影响因子： 4.4 最新[2023版] 5.1 最新五年平均 4.656 出版当年[2018版] 4.489 出版当年五年平均 4.649 出版前一年[2017版] 3.66 出版后一年[2019版]

第一作者：

第一作者机构： [1]Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China [2]Neuroelectrophysiological Laboratory, Xuanwu Hospital, Capital Medical University, Beijing, China [3]Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China

通讯作者：

通讯机构： [*1]Department of Neurology, University of Minnesota, 717 Delaware St. S.E., Minneapolis, MN 55455, USA [*2]Neuro-electrophysiology Laboratory, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053, China

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