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High Serum Tumor Necrosis Factor Receptor 1 Levels Are Related to Risk of Low Intrinsic Capacity in Elderly Adults

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收录情况： ◇ SCIE

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机构： [1]Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China

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关键词： biomarker chronic inflammation Intrinsic capacity older adults tumor necrosis factor receptor 1

摘要：

Objectives: To explore the association between inflammatory cytokines and intrinsic capacity in older adults. Method: Data were retrieved from the Cardiovascular Health, Cognition and Aging Study. A total of 130 participants aged 60–99 years (mean age 73.11±9.02 years) were recruited. Intrinsic capacity was assessed by the five domains recommended by the World Health Organization: locomotion, cognition, vitality, sensory and psychological domains. Circulating interleukin-6, tumor necrosis factor receptor 1 (TNFR1), insulin-like growth factor-1, and vaspin levels were measured. Logistic regression was conducted for factors associated with intrinsic capacity decline. Results: Intrinsic capacity decline was associated with older age, kidney diseases, olfactory disturbances and lower grip strength. Logistic regression showed that circulating TNFR1 was independently associated with intrinsic capacity decline after adjustments for age, sex, education, chronic diseases, grip strength, and physical activity. Conclusion: Elevated circulating TNFR1 levels are independently associated with declined intrinsic capacity, suggesting that chronic inflammation may underlie intrinsic capacity decline. © 2020, Serdi and Springer-Verlag International SAS, part of Springer Nature.

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出版当年[2020]版：

大类 | 3 区医学

小类 | 3 区老年医学 4 区营养学

最新[2023]版：

大类 | 3 区医学

小类 | 4 区老年医学 4 区营养学

JCR分区：

出版当年[2019]版：

Q3 NUTRITION & DIETETICS Q3 GERIATRICS & GERONTOLOGY

最新[2023]版：

Q1 GERIATRICS & GERONTOLOGY Q1 NUTRITION & DIETETICS

影响因子： 4.3 最新[2023版] 4.7 最新五年平均 2.791 出版当年[2019版] 3.021 出版当年五年平均 2.66 出版前一年[2018版] 4.075 出版后一年[2020版]

第一作者：

第一作者机构： [1]Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China [*1]Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, 45 Changchun Street, Xicheng District, Beijing 100053, China

通讯作者：

通讯机构： [1]Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China [*1]Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, 45 Changchun Street, Xicheng District, Beijing 100053, China

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