Based on the synergistic effect of Mg2+ and antibacterial peptides to improve the corrosion resistance, antibacterial ability and osteogenic activity of magnesium-based degradable metals.
机构：[a]Shaanxi Key Laboratory of biomedical metal materials, Northwest Institute for Nonferrous Metal Research, Xi’an 710016, P R China.[b]Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, 100871, China.[c]China–America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing 100053, China首都医科大学宣武医院中美神经科学研究所[d]Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China
To overcome the restricted degradation, poor antiacterial and osteoindctive problems of magnesium and its alloys, this study presented the spinning coating of an antimicrobial peptide (AP)-loaded silk fibroin (SF) composite onto a corrosion-resistant MgO-coated AZ31 Mg alloy via anodization (aMgO) and electrodeposition (eMgO) methods. The composite coatings not only created a smooth and hydrophilic surface, but also obviously improved the corrosion resistance according to the test of corrosion potential and current density. The colonization of E. coli on MgO-AP composite coatings was significantly reduced as compared to the MgO layers, due to the potential synergetic effects of APs and Mg2+. Compared with the bare AZ31, the composite coating inhibited the corrosion of the substrate and the release of Mg2+, supported the adhesion, spreading and proliferation of osteoblasts, and presented a significantly improved osteogenic differentiation trend. Therefore, the MgO-AP composite coating, which had both antibacterial and bone-promoting abilities, was expected to be applied for surface modification of magnesium alloy implants to solve the clinical problems of bacterial infection and poor osseointegration.
基金：
The authors acknowledge the financial support from the
National Key Research and Development Program of China
(2018YFC1105502), Innovative Talent Promotion Plan of
Shaanxi Province (2018KJXX-026) and International Science
and Technology Cooperation Base of Shaanxi Province
(2017GHJD-014). We sincerely appreciate Professor Huinan Liu
(University of California, Riverside, CA 92521) for providing
materials and experimental equipment.
第一作者机构：[a]Shaanxi Key Laboratory of biomedical metal materials, Northwest Institute for Nonferrous Metal Research, Xi’an 710016, P R China.
通讯作者：
推荐引用方式(GB/T 7714)：
Wenhao Zhou,Jianglong Yan,Yangyang Li,et al.Based on the synergistic effect of Mg2+ and antibacterial peptides to improve the corrosion resistance, antibacterial ability and osteogenic activity of magnesium-based degradable metals.[J].BIOMATERIALS SCIENCE.2021,9(3):807-825.doi:10.1039/d0bm01584a.
APA：
Wenhao Zhou,Jianglong Yan,Yangyang Li,Lan Wang,Lei Jing...&Yufeng Zheng.(2021).Based on the synergistic effect of Mg2+ and antibacterial peptides to improve the corrosion resistance, antibacterial ability and osteogenic activity of magnesium-based degradable metals..BIOMATERIALS SCIENCE,9,(3)
MLA：
Wenhao Zhou,et al."Based on the synergistic effect of Mg2+ and antibacterial peptides to improve the corrosion resistance, antibacterial ability and osteogenic activity of magnesium-based degradable metals.".BIOMATERIALS SCIENCE 9..3(2021):807-825
