机构：[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Chang Chun road 45, Xicheng, Beijing, China.神经科系统神经内科首都医科大学宣武医院[2]Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing 100053, China.[3]Department of China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.科技平台中美神经科学研究所首都医科大学宣武医院[4]Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.[5]Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Background: Antiphospholipid syndrome (APS) is associated with a high incidence of thrombotic events, either arterial thrombosis or venous thrombosis. However, APS-related non-thrombotic venous stenosis is rarely reported. Case presentation: This study described two cases of young women with APS-related internal jugular vein stenosis (IJVS) and reviewed current literature on this issue, including clinical features, diagnosis, and treatment. Conclusions: IJVS is a rather rare complication of APS. Two cases were reported for the first time that high titer of antiphospholipid antibodies (aPL) might mediate direct vessel wall damage and further induce venous stenosis despite long-term standardized anticoagulation to prevent thrombus formation. Therefore, dynamic monitoring of autoantibodies and concomitant use of anticoagulants and corticosteroids may be necessary to the management of APS and its complications.
基金：
National Key R&D Program of China [2017YFC1308400]; National Natural Science FoundationNational Natural Science Foundation of China (NSFC) [81371289]; Project of Beijing Municipal Top Talent for Healthy Work of China [20142-015]
第一作者机构：[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Chang Chun road 45, Xicheng, Beijing, China.[2]Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing 100053, China.[3]Department of China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
通讯作者：
推荐引用方式(GB/T 7714)：
Song Si-ying,Rajah Gary,Ding Yu-chuan,et al.The antiphospholipid syndrome may induce non-thrombotic internal jugular vein stenosis: two cases report[J].BMC NEUROLOGY.2021,21(1):9.doi:10.1186/s12883-020-02035-1.
APA：
Song, Si-ying,Rajah, Gary,Ding, Yu-chuan,Ji, Xun-ming&Meng, Ran.(2021).The antiphospholipid syndrome may induce non-thrombotic internal jugular vein stenosis: two cases report.BMC NEUROLOGY,21,(1)
MLA：
Song, Si-ying,et al."The antiphospholipid syndrome may induce non-thrombotic internal jugular vein stenosis: two cases report".BMC NEUROLOGY 21..1(2021):9
