详情页 - 首都医科大学宣武医院知识库

当前位置：首页 > 详情页

PLCG2 rs72824905 Variant Reduces the Risk of Alzheimer's Disease and Multiple Sclerosis.

72| 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China. [2]Department of Pathology, The Affiliated Hospital of Weifang Medical University, Weifang, China. [3]Department of Anesthesiology, The Affiliated Hospital of Weifang Medical University, Weifang, China. [4]Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China. [5]Chinese Institute for Brain Research, Beijing, China. [6]School of Medicine, School of Pharmaceutical Sciences, THU-PKU Center for Life Sciences, Tsinghua University, Beijing, China. [7]State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China. [8]Department of Pathophysiology, Peking Union Medical College, Beijing, China. [9]Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China. [10]School of Life Science and Technology, Harbin Institute of Technology, Harbin, China. [11]National Engineering Laboratory of Internet Medical Diagnosis and Treatment Technology, Xuanwu Hospital, Capital Medical University, Beijing, China.

出处：

DOI：

ISSN：

摘要：

We aimed to evaluate the association of PLCG2 rs72824905 variant with Alzheimer's disease (AD) and multiple sclerosis (MS) using large-scale genetic association study datasets. We selected 50,024 AD cases and 467,330 controls, and 32,367 MS cases and 36,012 controls. We found moderate heterogeneity of rs72824905 in different studies. We found significant association between rs72824905 G allele and reduced AD risk (OR = 0.66, 95% CI 0.59-0.74, p = 5.91E-14). Importantly, rs72824905 G allele could also significantly reduce the risk of MS with OR = 0.94, p = 3.63E-05. Hence, the effects of rs72824905 on AD and MS are consistent.

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2020]版：

大类 | 2 区医学

小类 | 3 区神经科学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区神经科学

JCR分区：

出版当年[2019]版：

Q2 NEUROSCIENCES

最新[2023]版：

Q2 NEUROSCIENCES

影响因子： 3.4 最新[2023版] 4.2 最新五年平均 3.909 出版当年[2019版] 4.023 出版当年五年平均 3.517 出版前一年[2018版] 4.472 出版后一年[2020版]

第一作者：

第一作者机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.

通讯作者：

通讯机构： [*1]Beijing Institute for Brain Disorders, Capital Medical University, Beijing, 100069, China [*2]School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, China.

推荐引用方式(GB/T 7714)：

APA：

MLA：