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Dissociable Auditory Cortico-Cerebellar Pathways in the Human Brain Estimated by Intrinsic Functional Connectivity.

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机构： [1]National Engineering Laboratory for Neuromodulation, School of Aerospace Engineering, Tsinghua University, 100084 Beijing, China. [2]Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. [3]Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA. [4]Department of Automation Sciences and Electrical Engineering, Beihang University, 100083 Beijing, China. [5]Department of Neurosurgery, Comprehensive Epilepsy Center, Sanbo Brain Hospital, Capital Medical University, 100093 Beijing, China. [6]Department of Neurology, Xuanwu Hospital of Capital Medical University, 100053 Beijing, China. [7]Psychotic Disorders Division, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA. [8]Precision Medicine & Healthcare Research Center, Tsinghua-Berkeley Shenzhen Institute, Tsinghua University, 518055 Shenzhen, China. [9]IDG/McGovern Institute for Brain Research at Tsinghua University, 100084 Beijing, China.

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The cerebellum, a structure historically associated with motor control, has more recently been implicated in several higher-order auditory-cognitive functions. However, the exact functional pathways that mediate cerebellar influences on auditory cortex (AC) remain unclear. Here, we sought to identify auditory cortico-cerebellar pathways based on intrinsic functional connectivity magnetic resonance imaging. In contrast to previous connectivity studies that principally consider the AC as a single functionally homogenous unit, we mapped the cerebellar connectivity across different parts of the AC. Our results reveal that auditory subareas demonstrating different levels of interindividual functional variability are functionally coupled with distinct cerebellar regions. Moreover, auditory and sensorimotor areas show divergent cortico-cerebellar connectivity patterns, although sensorimotor areas proximal to the AC are often functionally grouped with the AC in previous connectivity-based network analyses. Lastly, we found that the AC can be functionally segmented into highly similar subareas based on either cortico-cerebellar or cortico-cortical functional connectivity, suggesting the existence of multiple parallel auditory cortico-cerebellar circuits that involve different subareas of the AC. Overall, the present study revealed multiple auditory cortico-cerebellar pathways and provided a fine-grained map of AC subareas, indicative of the critical role of the cerebellum in auditory processing and multisensory integration. © The Author(s) 2021. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.

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出版当年[2020]版：

大类 | 2 区

医学

小类 | 2 区神经科学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区神经科学

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出版当年[2019]版：

Q1 NEUROSCIENCES

最新[2024]版：

Q2 NEUROSCIENCES

影响因子： 2.9 最新[2024版] 3.4 最新五年平均 5.043 出版当年[2019版] 5.924 出版当年五年平均 5.437 出版前一年[2018版] 5.357 出版后一年[2020版]

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第一作者机构： [1]National Engineering Laboratory for Neuromodulation, School of Aerospace Engineering, Tsinghua University, 100084 Beijing, China. [2]Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

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