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Prognostic role of EYA4 in lower grade glioma with IDH1 mutation and 1p19q co-deletion.

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机构： [1]Beijing Institute of Functional Neurosurgery, Department of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China. [2]School of Clinical Medicine,Tsinghua University, Beijing, China. [3]Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. [4]Department of Neurosurgery, Yuquan Hospital, Tsinghua University, Beijing, China

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Eyes absent 4 (EYA4) participates an important role in various cancers .Patients with low EYA4 expression have significantly favorable prognosis compared with those with high EYA4 expression.However, the expression and role of EYA4 in lower grade glioma (LGG) has not been fully elucidated. The R2 and UCSC Xena browser based on data from 284 cases in GSE16011 from GEO datasets and 530 cases of LGG patients in The Cancer Genome Atlas database (TCGA) were extracted for bioinformatic analysis. The EYA4 expression in different subtypes of LGG was detected. Kaplan-Meier survival curves were generated to explore the association between EYA4 expression and OS in both datasets. LGG patients with lower EYA4 expression had significantly longer 5- and 10-year OS in two datasets (p<0.001). By matching histological subtypes and gene expression profiles of LGG patients, oligoastrocytoma and oligodendroglioma groups had lower EYA4 expression and longer OS compared with astrocytoma group (p<0.05). Patients with IDH1 mutations and 1p19q co-deletion had longer 5- and 10-year OS (p <0.001), and EYA4 expression was significantly down-regulated in these patients (p<0.001). This study suggests that EYA4 can be used as a prognostic marker and provide a potential therapeutic target in LGG patients with IDH1 mutation and 1p19q co-deletion. Copyright © 2021 Elsevier Inc. All rights reserved.

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出版当年[2020]版：

大类 | 4 区医学

小类 | 4 区临床神经病学 4 区外科

最新[2023]版：

大类 | 4 区医学

小类 | 4 区临床神经病学 4 区外科

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出版当年[2019]版：

Q3 SURGERY Q3 CLINICAL NEUROLOGY

最新[2023]版：

Q2 SURGERY Q3 CLINICAL NEUROLOGY

影响因子： 1.9 最新[2023版] 2 最新五年平均 1.829 出版当年[2019版] 2.074 出版当年五年平均 1.723 出版前一年[2018版] 2.104 出版后一年[2020版]

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第一作者机构： [1]Beijing Institute of Functional Neurosurgery, Department of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.

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通讯作者：

通讯机构： [4]Department of Neurosurgery, Yuquan Hospital, Tsinghua University, Beijing, China [*1]Department of Neurosurgery, Yuquan Hospital, Tsinghua University, Beijing, China

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