机构：[1]Department of General Surgery, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.外科系统普通外科首都医科大学宣武医院[2]School of Public Health, Xiangnan University, Chenzhou, Hunan 423000, China
出处：
ISSN：
摘要：
Pancreatic cancer is the 7th leading cause of cancer-related death worldwide. Aberrant expressions of transmembrane 176A (TMEM176A) were found in multiple cancer types. However, the expression and function of TMEM176A remain unclear in pancreatic cancer.
Immunohistochemistry, flow cytometry, western blot, and transwell were applied on investigating samples from pancreatic cancer patients and pancreatic cancer cell lines.
Analysis based on the TCGA database showed that a high level of TMEM176A was associated with a better relapse-free survival rate (P = 0.012). Further, the results of tissue microarray showed patients with a high level of TMEM176A were associated with lymph node metastasis (P = 0.045) and a better overall survival rate (P = 0.032). Overexpression of TMEM176A in Capan-1 and PANC-1 cells suppressed cell proliferation, cell invasion, and migration, and induced apoptosis in pancreatic cancer cells. TMEM176A suppressed ERK signaling in pancreatic cancer.
TMEM176A suppresses the growth and migration of pancreatic cancer cells by inhibiting ERK signaling.
基金：
National Natural science foundation of China (grant number 81272756) and Beijing Natural Science Foundation (grant number 7162076).
第一作者机构：[1]Department of General Surgery, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.
通讯作者：
通讯机构：[1]Department of General Surgery, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.[*1]Department of General Surgery, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.
推荐引用方式(GB/T 7714)：
Guo Yulin,Cao Feng,Hu Shun,et al.TMEM176A acts as a tumor suppressor gene in pancreatic cancer by inhibiting ERK signaling.[J].DISCOVERY MEDICINE.2020,30(161):145-153.
APA：
Guo Yulin,Cao Feng,Hu Shun,Liu Shuang,Sun Haichen...&Li Fei.(2020).TMEM176A acts as a tumor suppressor gene in pancreatic cancer by inhibiting ERK signaling..DISCOVERY MEDICINE,30,(161)
MLA：
Guo Yulin,et al."TMEM176A acts as a tumor suppressor gene in pancreatic cancer by inhibiting ERK signaling.".DISCOVERY MEDICINE 30..161(2020):145-153
