机构：[1]State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing 100190 China[2]University of Chinese Academy of Sciences, Beijing 100049, China[3]Department of Neurobiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China首都医科大学宣武医院[4]Wincon TheraCells Biotechnologies Co., Ltd., Nanning 530002, China
出处：
ISSN：
摘要：
Parkinson's disease (PD) is characterized by excessively synchronized neural activity. In this paper, we recorded electrophysiological signals in Cortex of normal and PD mode monkey using homemade implantable microelectrode arrays (MEA), and analyzed the characteristics of action potentials (APs) and local field potentials (LFPs). Results showed that, comparing to normal monkey, the spike-firing activity of PD mode monkey could be divided into two stages: the continuous spike-firing stage and the burst spike-firing stage. The continuous spike-firing lasted for about 20s and oscillated at low frequency about 0.03Hz. APs fired in a burst mode between two continuous discharges. In the continuous spike-firing stage, the spike-firing activity was related to the ripple rhythm (100-200Hz) of LFPs with a coherence 0.86, while, in the burst spike-firing stage, it was related to the phase of theta rhythm (4-7 Hz). APs tended to discharge in the valley of theta rhythm (average peak phase is -10 degrees).
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [61527815, 61960206012, 61971400, 61975206, 61973292]; National Key Research and Development Program [2017YFA0205902]; Key Research Programs of Frontier Sciences, CAS [QYZDJ-SSW-SYS015]
第一作者机构：[1]State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing 100190 China[2]University of Chinese Academy of Sciences, Beijing 100049, China
通讯作者：
推荐引用方式(GB/T 7714)：
Xu Shengwei,Zhang Yu,Xiao Guihua,et al.Research on the Characteristics of Action Potentials and Local Field Potentials in Cortex of Parkinson's Disease Mode Monkey[J].42ND ANNUAL INTERNATIONAL CONFERENCES OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY: ENABLING INNOVATIVE TECHNOLOGIES FOR GLOBAL HEALTHCARE EMBC'20.2020,880-883.
APA：
Xu, Shengwei,Zhang, Yu,Xiao, Guihua,Duan, Yiming,Wang, Mixia...&Cai, Xinxia.(2020).Research on the Characteristics of Action Potentials and Local Field Potentials in Cortex of Parkinson's Disease Mode Monkey.42ND ANNUAL INTERNATIONAL CONFERENCES OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY: ENABLING INNOVATIVE TECHNOLOGIES FOR GLOBAL HEALTHCARE EMBC'20,,
MLA：
Xu, Shengwei,et al."Research on the Characteristics of Action Potentials and Local Field Potentials in Cortex of Parkinson's Disease Mode Monkey".42ND ANNUAL INTERNATIONAL CONFERENCES OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY: ENABLING INNOVATIVE TECHNOLOGIES FOR GLOBAL HEALTHCARE EMBC'20 .(2020):880-883
