To explore the effect of nursing intervention on the treatment of lumbar disc herniation with radiofrequency thermocoagulation. The clinical data of 87 patients diagnosed with lumbar disc herniation treated at our hospital from February 2018 to September 2019 were collected and divided into the control group (n=43) and the observation group (n=44) according to the randomized double-blind method. The control group was treated with routine nursing intervention, and the observation group was treated with comprehensive nursing, the changes of lumbar vertebra function, complications, and quality of life after 1 and 3 mo of intervention treatment were observed. At the same time, the pain degree of the two groups was evaluated 7 d after the operation. The results showed that the Oswestry disability index of the two groups decreased significantly 1 mo and 3 mo after the operation (p<0.05), the score and the incidence of complications in the observation group was significantly lower than that in the control group. On the 7th d after the operation, the visual analog scale score of the observation group was significantly lower than that of the control group, and the difference between the two groups was statistically significant (p<0.05). After intervention treatment, the scores of quality of life in the control group and the observation group were significantly improved, and the quality of life in the observation group was significantly better than that in the control group (p<0.05). The establishment of a correct and effective rehabilitation intervention program after the operation cannot only significantly reduce the degree of pain and the risk of complications, but also significantly improve the quality of life of patients, which is worth popularizing and applying in the clinic.