机构：[1]Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China首都医科大学附属天坛医院[2]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China首都医科大学附属天坛医院[3]Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China首都医科大学附属天坛医院[4]Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China[5]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China医技科室放射科首都医科大学宣武医院[6]Department of Radiology, The First Affiliated Hospital, Nanchang University, Nanchang, China/ Neuroimaging Lab, Jiangxi Province Medical Imaging Research Institute, Nanchang, China[7]Department of Radiology,The First Affiliated Hospital of Chongqing Medical University, Chongqing, China重庆医科大学附属第一医院[8]Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China[9]Department of Neurology, China-Japan Union hospital of Jilin University, Changchun, China吉林大学中日联谊医院[10]Centre d’Imagerie Médicale de Cornavin, Geneva, Switzerland/ Department of Surgical Sciences, Radiology, Uppsala University, Sweden/Faculty of Medicine of the University of Geneva, Switzerland/ Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China首都医科大学附属天坛医院[11]Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, The Netherlands/Queen Square Institute of Neurology and Center for Medical Image Computing, University College London, London, UK
Background: Hippocampal involvement may differ between multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). Objective: To investigate the morphometric, diffusion and functional alterations in hippocampus in MS and NMOSD and the clinical significance. Methods: A total of 752 participants including 236 MS, 236 NMOSD and 280 healthy controls (HC) were included in this retrospective multi-center study. The hippocampus and subfield volumes, fractional anisotropy (FA) and mean diffusivity (MD), amplitude of low frequency fluctuation (ALFF) and degree centrality (DC) were analyzed, and their associations with clinical variables were investigated. Results: The hippocampus showed significantly lower volume, FA and greater MD in MS compared to NMOSD and HC (p < 0.05), while no abnormal ALFF or DC was identified in any group. Hippocampal subfields were affected in both diseases, though subiculum, presubiculum and fimbria showed significantly lower volume only in MS (p < 0.05). Significant correlations between diffusion alterations, several subfield volumes and clinical variables were observed in both diseases, especially in MS (R = -0.444 to 0.498, p < 0.05). FA and MD showed fair discriminative power between MS and HC, NMOSD and HC (AUC > 0.7). Conclusions: Hippocampal atrophy and diffusion abnormalities were identified in MS and NMOSD, partly explaining how clinical disability and cognitive impairment are differentially affected.
基金：
This work was supported by the
National Science Foundation of China (Nos.
81870958 and 81571631), the Beijing Natural Science
fund (No.7133244), the Beijing Nova Program
(xx2013045), and the Shanghai new star of Medical
Court (2018, H. L.). F.B. is supported by the NIHR
biomedical research center at UCLH.
第一作者机构：[1]Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[3]Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China[*1]Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, No.119, the West Southern 4th Ring Road, Fengtai District, Beijing 100070, China.
推荐引用方式(GB/T 7714)：
Fenglian Zheng,Yuxin Li,Zhizheng Zhuo,et al.Structural and functional hippocampal alterations in Multiple sclerosis and neuromyelitis optica spectrum disorder[J].MULTIPLE SCLEROSIS JOURNAL.2022,28(5):707-717.doi:10.1177/13524585211032800.
APA：
Fenglian Zheng,Yuxin Li,Zhizheng Zhuo,Yunyun Duan,Guanmei Cao...&Yaou Liu.(2022).Structural and functional hippocampal alterations in Multiple sclerosis and neuromyelitis optica spectrum disorder.MULTIPLE SCLEROSIS JOURNAL,28,(5)
MLA：
Fenglian Zheng,et al."Structural and functional hippocampal alterations in Multiple sclerosis and neuromyelitis optica spectrum disorder".MULTIPLE SCLEROSIS JOURNAL 28..5(2022):707-717
