机构：[1]Post-doctoral Research Center, Department of Radiology, Longgang Central Hospital, Shenzhen Clinical Medical Institute, Guangzhou University of Chinese Medicine, Shenzhen, China,深圳市康宁医院深圳医学信息中心[2]Department of Radiology, The Third Medical Centre of Chinese PLA General Hospital, Beijing, China,[3]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China,医技科室放射科首都医科大学宣武医院[4]Department of Radiology, University of Washington, Seattle, WA, United States,[5]Zhouxin Medical Imaging and Health Screening Centre, Xiamen, China,[6]Keck School of Medicine, University of Southern California, Los Angeles, CA, United States
Background: Quantification of cardiac structure and function is essential for diagnostic interpretation and clinical decision making. We sought to establish cardiovascular magnetic resonance (CMR) reference values of left and right ventricular (LV and RV) morphology and function based on a large sample of healthy Chinese adults. Methods: Five hundred fifty validated healthy Chinese adults (aged 21-70 years; 323 men) free of hypertension, diabetes, and obesity were included in this study. All the subjects were stratified by gender (men and women) and age decades. On cine CMR, measurements of biventricular end-diastolic, end-systolic, and stroke volumes (EDV, ESV, and SV), ejection fraction (EF), and end-diastolic LV wall thickness (LVWT) and mass (LVM) were obtained. Results: Men had greater LVEDV (111.6 +/- 19.8 vs. 94.6 +/- 15.6 ml), LVESV (36.5 +/- 9.8 vs. 28.2 +/- 7.9 ml), LVM (121.1 +/- 19.9 vs. 86.1 +/- 14.5 g), global end-diastolic LVWT (8.1 +/- 1.1 vs. 6.7 +/- 1.0 mm), RVEDV (128.0 +/- 23.6 vs. 101.7 +/- 17.0 ml), and RVESV (53.5 +/- 13.7 vs. 36.8 +/- 8.9 ml), while women had greater LVEF (67.5 & PLUSMN; 5.4 vs. 70.4 +/- 5.7%) and RVEF (58.5 +/- 5.2 vs. 64.0 +/-& nbsp;5.3%) (all p < 0.001). For both men and women, age was negatively correlated with LVEDV (r = -0.31 and r = -0.32), LVESV (r = -0.37 and r = -0.47), RVEDV (r = -0.31 and r = -0.29), and RVESV (r = -0.33 and r = -0.44), while it was positively correlated with LVEF (r = 0.28 and r = 0.43) and RVEF (r = 0.28 and r = 0.41) (all p < 0.001). Aging was associated with increasing global end-diastolic LVWT and LVM/LVEDV in both sexes (all p < 0.001). Older age was associated with increasing LVM only in women (r = 0.36, p < 0.001), not in men (r = 0.05, p = 0.359). Conclusions: We systematically provide age-, sex-, and body size-specific CMR reference values for biventricular morphology and function based on a large sample of healthy Chinese adults. Biventricular structure and function are significantly associated with age and sex.
第一作者机构：[1]Post-doctoral Research Center, Department of Radiology, Longgang Central Hospital, Shenzhen Clinical Medical Institute, Guangzhou University of Chinese Medicine, Shenzhen, China,
通讯作者：
通讯机构：[3]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China,[5]Zhouxin Medical Imaging and Health Screening Centre, Xiamen, China,[6]Keck School of Medicine, University of Southern California, Los Angeles, CA, United States
推荐引用方式(GB/T 7714)：
Zhen Zhang,Qiaozhi Ma,Yiyuan Gao,et al.Biventricular Morphology and Function Reference Values Derived From a Large Sample of Healthy Chinese Adults by Magnetic Resonance Imaging[J].FRONTIERS IN CARDIOVASCULAR MEDICINE.2021,8:doi:10.3389/fcvm.2021.697481.
APA：
Zhen Zhang,Qiaozhi Ma,Yiyuan Gao,Lizhen Cao,Chengcheng Zhu...&Kuncheng Li.(2021).Biventricular Morphology and Function Reference Values Derived From a Large Sample of Healthy Chinese Adults by Magnetic Resonance Imaging.FRONTIERS IN CARDIOVASCULAR MEDICINE,8,
MLA：
Zhen Zhang,et al."Biventricular Morphology and Function Reference Values Derived From a Large Sample of Healthy Chinese Adults by Magnetic Resonance Imaging".FRONTIERS IN CARDIOVASCULAR MEDICINE 8.(2021)
