机构：[1]Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China外科系统普通外科首都医科大学宣武医院[2]Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. Jilin Biomedical Polymers Engineering Laboratory, Changchun 130022, China[3]College of Chemistry, Northeast Normal University, Changchun 130024, China[4]Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. University of Science and Technology of China, Hefei 230026, China[5]Laboratory of Biomaterials and Translational Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China中山大学附属第三医院[6]Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun 130000, China[7]Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. Jilin Biomedical Polymers Engineering Laboratory, Changchun 130022, China[8]Department of Gastrointestinal and Colorectal Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, China吉林大学中日联谊医院[9]Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. Jilin Biomedical Polymers Engineering Laboratory, Changchun 130022, China.University of Science and Technology of China, Hefei 230026, China[10]Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. Jilin Biomedical Polymers Engineering Laboratory, Changchun 130022, China[11]Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, United States
Gut bacteria and their metabolites influence the immune microenvironment of liver through the gut-liver axis, thus representing emerging therapeutic targets for liver cancer therapy. However, directly manipulating gut microbiota or their metabolites is not practical in clinic since the safety concerns and the complicated mechanism of action. Considering the dysregulated bile acid profiles associated with liver cancer, here we propose a strategy that directly manipulates the primary and secondary bile acid receptors through nanoapproach as an alternative and more precise way for liver cancer therapy. We show that nanodelivery of bile acid receptor modulators elicited robust antitumor immune responses and significantly changed the immune microenvironment in the murine hepatic tumor. In addition, ex vivo stimulation on both murine and patient hepatic tumor tissues suggests the observation here may be meaningful for clinical practice. This study elucidates a novel and precise strategy for liver cancer immunotherapy.
基金：
This work was financially supported by the National Natural
Science Foundation of China (51973215, 52025035,
52003268, 51829302, and 51833010), Bureau of International C o o p e r a t i o n Ch i n e s e A c a d e m y o f S c i e n c e
(121522KYSB20200029), the Jilin Province Science and
Technology Development Plan (2020122331JC), the Youth
Innovation Promotion Association of Chinese Academy of
Sciences (2020232), as well as the support from the National
Institutes of Health (CA189999).
第一作者机构：[1]Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
通讯作者：
通讯机构：[10]Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. Jilin Biomedical Polymers Engineering Laboratory, Changchun 130022, China[11]Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, United States[*1]Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. Jilin Biomedical Polymers Engineering Laboratory, Changchun 130022, China[*2]Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, United States
推荐引用方式(GB/T 7714)：
Guofeng Ji,Xinghui Si,Si Dong,et al.Manipulating Liver Bile Acid Signaling by Nanodelivery of Bile Acid Receptor Modulators for Liver Cancer Immunotherapy.[J].NANO LETTERS.2021,21(16):6781-6791.doi:10.1021/acs.nanolett.1c01360.
APA：
Guofeng Ji,Xinghui Si,Si Dong,Yajun Xu,Mingqiang Li...&Xuesi Chen.(2021).Manipulating Liver Bile Acid Signaling by Nanodelivery of Bile Acid Receptor Modulators for Liver Cancer Immunotherapy..NANO LETTERS,21,(16)
MLA：
Guofeng Ji,et al."Manipulating Liver Bile Acid Signaling by Nanodelivery of Bile Acid Receptor Modulators for Liver Cancer Immunotherapy.".NANO LETTERS 21..16(2021):6781-6791
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