机构：[a]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China神经科系统神经内科首都医科大学宣武医院[b]Institute of Biomedical Engineering, School of Communication and Information Engineering, Shanghai University, Shanghai, China[c]Biomedical Engineering Institute, Hainan University, Haikou, China[d]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China[e]National Clinical Research Center for Geriatric Disorders, Beijing, China
Mounting evidence suggests that sex differences exist in cognitive reserve (CR) for cognitively unimpaired (CU) elderly individuals. Global left frontal connectivity (gLFC connectivity) is a reliable neural substrate of CR.The purpose of this study was to explore sex differences in gLFC connectivity among CU elderly individuals.One hundred thirteen normal controls (NCs) (women = 66) and 132 individuals with subjective cognitive decline (SCD) (women = 92) were recruited from the Sino Longitudinal Study on Cognitive Decline (SILCODE) (data 1). Among them, 88 subjects underwent amyloid-β (Aβ) imaging, including 32 Aβ+ and 56 Aβ-subjects. Forty-six subjects underwent another rs-fMRI examination (data 2) to validate the repeatability of the calculation of gLFC connectivity, which was determined through seed-based functional connectivity between the LFC and voxels throughout the whole brain. Independent-sample t-tests were used to evaluate the sex differences in gLFC connectivity across different subgroups (NC versus SCD, Aβ+ versus Aβ-). Partial correlation analysis was used to calculate the correlations between gLFC connectivity and cognitive assessments.Women exhibited lower gLFC connectivity in both the NC (p = 0.001) and SCD (p = 0.020) subgroups than men. Women also exhibited lower gLFC connectivity in both the Aβ-(p = 0.006) and Aβ+ (p = 0.025) groups. However, the significant difference disappeared in the Aβ+ group when considering the covariates of age, education, total intracranial volume, and APOE4-carrying status. In addition, gLFC connectivity values were negatively correlated with Geriatric Depression Scale scores in the SCD group (r = -0.176, p = 0.047).Women showed lower gLFC connectivity among CU elderly individuals.
基金：
This work was supported by the National Natu- 443
ral Science Foundation of China (Grant 61633018, 444
61603236, 82001773 and 82020108013) 111 Project 445
(D20031).
第一作者机构：[a]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China
通讯作者：
通讯机构：[a]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China[b]Institute of Biomedical Engineering, School of Communication and Information Engineering, Shanghai University, Shanghai, China[c]Biomedical Engineering Institute, Hainan University, Haikou, China[d]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China[e]National Clinical Research Center for Geriatric Disorders, Beijing, China[*1]Department of Neurology, XuanWu Hospital of Capital Medical University, No.45 Changchun Street, Xicheng District, Beijing 100053, China.[*2]Institute of Biomedical Engineering, School of Communication and Information Engineering, Shanghai University, 99 Shangda Road, Shanghai 200444, China.
推荐引用方式(GB/T 7714)：
Wenying Du,Changchang Ding,Jiehui Jiang,et al.Women Exhibit Lower Global Left Frontal Cortex Connectivity Among Cognitively Unimpaired Elderly Individuals: A Pilot Study from SILCODE.[J].JOURNAL OF ALZHEIMERS DISEASE.2021,83(2):653-663.doi:10.3233/JAD-210376.
APA：
Wenying Du,Changchang Ding,Jiehui Jiang&Ying Han.(2021).Women Exhibit Lower Global Left Frontal Cortex Connectivity Among Cognitively Unimpaired Elderly Individuals: A Pilot Study from SILCODE..JOURNAL OF ALZHEIMERS DISEASE,83,(2)
MLA：
Wenying Du,et al."Women Exhibit Lower Global Left Frontal Cortex Connectivity Among Cognitively Unimpaired Elderly Individuals: A Pilot Study from SILCODE.".JOURNAL OF ALZHEIMERS DISEASE 83..2(2021):653-663
