The association between BDNF levels and risperidone-induced weight gain is dependent on the BDNF Val66Met polymorphism in antipsychotic-naive first episode schizophrenia patients: a 12-week prospective study
机构：[1]The Affiliated Kangning Hospital of Wenzhou Medical University, Wenzhou, China[2]Neurology Department, Xuan Wu Hospital of Capital Medical University, Beijing, China神经科系统神经内科首都医科大学宣武医院[3]Qingdao Mental Health Center, Qingdao University, Qingdao, China[4]Peking University HuiLongGuan Clinical Medical School, Beijing HuiLongGuan Hospital, Beijing, China[5]CASKey Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Science, Beijing, China
A growing number of studies have shown that brain-derived neurotrophic factor (BDNF) is associated with weight gain during antipsychotic treatment in schizophrenia patients. However, there is still a lack of research results in the initial stage of antipsychotic treatment. This study aimed to evaluate the relationship between weight gain caused by risperidone monotherapy for 12 weeks and BDNF level in antipsychotic-naive and first-episode (ANFE) patients with schizophrenia, and we hypothesize that this may depend on BDNF Val66Met gene polymorphism. In a 12-week longitudinal trial, 225 ANFE patients were enrolled and treated with risperidone. Body weight was measured at baseline and during the 12-week follow-up. After treatment, the average weight of ANFE patients increased by 2.6 kg. Furthermore, we found that in patients with Val/Val genotype, the increase in serum BDNF levels was negatively correlated with risperidone-induced weight gain (r = -0.44, p = 0.008). Regression analysis showed that the baseline BDNF level was a predictor of weight gain after treatment (beta = -0.45, t = -3.0, p = 0.005). Our results suggest that the BDNF signaling may be involved in weight gain caused by risperidone treatment. Furthermore, the negative association between weight gain and increased BDNF levels during risperidone treatment in ANFE schizophrenia depends on the BDNF Val66Met polymorphism.
第一作者机构：[1]The Affiliated Kangning Hospital of Wenzhou Medical University, Wenzhou, China
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推荐引用方式(GB/T 7714)：
Liu Jiahong,Wang Pingping,Sun Leilei,et al.The association between BDNF levels and risperidone-induced weight gain is dependent on the BDNF Val66Met polymorphism in antipsychotic-naive first episode schizophrenia patients: a 12-week prospective study[J].TRANSLATIONAL PSYCHIATRY.2021,11(1):doi:10.1038/s41398-021-01585-3.
APA：
Liu, Jiahong,Wang, Pingping,Sun, Leilei,Guan, Xiaoni,Xiu, Meihong&Zhang, Xiangyang.(2021).The association between BDNF levels and risperidone-induced weight gain is dependent on the BDNF Val66Met polymorphism in antipsychotic-naive first episode schizophrenia patients: a 12-week prospective study.TRANSLATIONAL PSYCHIATRY,11,(1)
MLA：
Liu, Jiahong,et al."The association between BDNF levels and risperidone-induced weight gain is dependent on the BDNF Val66Met polymorphism in antipsychotic-naive first episode schizophrenia patients: a 12-week prospective study".TRANSLATIONAL PSYCHIATRY 11..1(2021)
医学